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On the Efficiency of NHS Ester Cross-Linkers for Stabilizing Integral Membrane Protein Complexes

Chen, Fan ; Gerber, Sabina ; Korkhov, Volodymyr ; Mireku, Samantha ; Bucher, Monika ; Locher, Kaspar ; Zenobi, Renato

In: Journal of The American Society for Mass Spectrometry, 2015, vol. 26, no. 3, p. 493-498

Generation and tumor recognition properties of two human monoclonal antibodies specific to cell surface anionic phospholipids

Bujak, Emil ; Pretto, Francesca ; Neri, Dario

In: Investigational New Drugs, 2015, vol. 33, no. 4, p. 791-800

Proteoliposomes - a system to study membrane proteins under buffer gradients by cryo-EM

Sejwal, Kushal ; Chami, Mohamed ; Baumgartner, Paul ; Kowal, Julia ; Müller, Shirley A. ; Stahlberg, Henning

In: Nanotechnology Reviews, 2017, vol. 6, no. 1, p. 57-74

Herpes simplex virus enhances chemokine function through modulation of receptor trafficking and oligomerization

Martinez-Martin, Nadia ; Viejo-Borbolla, Abel ; Martín, Rocío ; Soledad, Blanco ; Benovic, Jeffrey L. ; Thelen, Marcus ; Alcamí, Antonio

In: Nature communications, 2015, vol. 6, p. 6163

Glycoprotein G (gG) from herpes simplex virus 1 and 2 (HSV-1 and HSV-2, important human neurotropic pathogens) is the first viral chemokine-binding protein found to potentiate chemokine function. Here we show that gG attaches to cell surface glycosaminoglycans and induces lipid raft clustering, increasing the incorporation of CXCR4 receptors into these microdomains. gG induces conformational...

The inflammatory response of lymphatic endothelium

Aebischer, David ; Iolyeva, Maria ; Halin, Cornelia

In: Angiogenesis, 2014, vol. 17, no. 2, p. 383-393

Cell-Free Microfluidic Determination of P-glycoprotein Interactions with Substrates and Inhibitors

Eyer, Klaus ; Herger, Michael ; Krämer, Stefanie ; Dittrich, Petra

In: Pharmaceutical Research, 2014, vol. 31, no. 12, p. 3415-3425

Improving the Stability and Activity of Oral Therapeutic Enzymes—Recent Advances and Perspectives

Fuhrmann, Gregor ; Leroux, Jean-Christophe

In: Pharmaceutical Research, 2014, vol. 31, no. 5, p. 1099-1105

Cholesterol Transport and Regulation in the Mammary Gland

Ontsouka, Edgar ; Albrecht, Christiane

In: Journal of Mammary Gland Biology and Neoplasia, 2014, vol. 19, no. 1, p. 43-58

Lymphatic vessels: new targets for the treatment of inflammatory diseases

Dieterich, Lothar ; Seidel, Catharina ; Detmar, Michael

In: Angiogenesis, 2014, vol. 17, no. 2, p. 359-371

Influenza hemagglutinin membrane anchor

Benton, Donald J. ; Nans, Andrea ; Calder, Lesley J. ; Turner, Jack ; Neu, Ursula ; Lin, Yi Pu ; Ketelaars, Esther ; Kallewaard, Nicole L. ; Corti, Davide ; Lanzavecchia, Antonio ; Gamblin, Steven J. ; Rosenthal, Peter B. ; Skehel, John J.

In: Proceedings of the national academy of sciences of the United States of America, 2018, vol. 115, no. 40, p. 10112-10117

Viruses with membranes fuse them with cellular membranes, to transfer their genomes into cells at the beginning of infection. For Influenza virus, the membrane glycoprotein involved in fusion is the hemagglutinin (HA), the 3D structure of which is known from X-ray crystallographic studies. The soluble ectodomain fragments used in these studies lacked the “membrane anchor” portion of the...