In: Human Molecular Genetics, 2017, vol. 26, no. 3, p. 582-598
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In: Brain, 2016, vol. 139, no. 5, p. 1587-1604
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In: Molecular Autism, 2020, vol. 11, no. 1, p. 47
In fast firing, parvalbumin (PV)-expressing (Pvalb) interneurons, PV acts as an intracellular Ca2+ signal modulator with slow-onset kinetics. In Purkinje cells of PV−/− mice, adaptive/homeostatic mechanisms lead to an increase in mitochondria, organelles equally capable of delayed Ca2+ sequestering/buffering. An inverse regulation of PV and mitochondria likewise operates in cell model...
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In: Acta Neuropathologica, 2014, vol. 127, no. 2, p. 299-301
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In: Psychopharmacology, 2014, vol. 231, no. 15, p. 2955-2965
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In: Mammalian Genome, 2014, vol. 25, no. 9-10, p. 424-433
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In: Neurobiology of Aging, 2019, vol. 76, p. 80–95
Olfaction declines with aging and appears to be a prodromal sign of cognitive decline in progressive neurodegenerative diseases. Nevertheless, very little is known about the pathophysiological changes underlying smell loss that may reflect early network dysfunction. A cross-sectional histoanatomical study was conducted on postmortem olfactory nerves of patients with increasing severity of...
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In: Cellular and Molecular Life Sciences, 2018, vol. 75, no. 24, p. 4643–4666
The Ca2+-binding protein parvalbumin (PV) and mitochondria play important roles in Ca2+ signaling, buffering and sequestration. Antagonistic regulation of PV and mitochondrial volume is observed in in vitro and in vivo model systems. Changes in mitochondrial morphology, mitochondrial volume and dynamics (fusion, fission, mitophagy) resulting from modulation of PV were investigated in MDCK...
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Thèse de doctorat : Università della Svizzera italiana, 2018 ; 2018INFO017.
The worldwide significant increase in life expectancy has recently drawn the attention of the scientific community to neurodegenerative pathologies of the elderly population. These neurodegenerative disorders arise from the abnormal protein aggregation in the nervous tissue leading to intracellular inclusions or extracellular aggregates in specific brain areas. A feasible strategy to prevent...
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In: Pflügers Archiv - European Journal of Physiology, 2012, vol. 464, no. 1, p. 19-26
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