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Consortium of Swiss Academic Libraries

Depression as a risk factor for acute coronary syndrome: a review

Misteli, Genny ; Stute, Petra

In: Archives of Gynecology and Obstetrics, 2015, vol. 291, no. 6, p. 1213-1220

Université de Fribourg

The transcriptional regulator CBX2 and ovarian function: A whole genome and whole transcriptome approach

Bouazzi, Leila ; Sproll, Patrick ; Eid, Wassim ; Biason-Lauber, Anna

In: Scientific Reports, 2019, vol. 9, no. 1, p. 1–18

The chromobox homolog 2 (CBX2) was found to be important for human testis development, but its role in the human ovary remains elusive. We conducted a genome-wide analysis based on DNA adenine methyltransferase identification (DamID) and RNA sequencing strategies to investigate CBX2 in the human granulosa cells. Functional analysis revealed that CBX2 was upstream of genes contributing to ...

Consortium of Swiss Academic Libraries

Treatment of Primary CNS Lymphoma

Roth, Patrick ; Stupp, Roger ; Eisele, Günter ; Weller, Michael

In: Current Treatment Options in Neurology, 2014, vol. 16, no. 1, p. 1-14

Université de Fribourg

Early-onset complete ovarian failure and lack of puberty in a woman with mutated estrogen receptor β (esr2)

Lang-Muritano, Mariarosaria ; Sproll, Patrick ; Wyss, Sascha ; Kolly, Anne ; Hürlimann, Renate ; Konrad, Daniel ; Biason-Lauber, Anna

In: The Journal of Clinical Endocrinology & Metabolism, 2018, vol. 103, no. 10, p. 3748–3756

Estrogen resistance due to mutations in the estrogen receptor α gene (ESR1) has been described in men and women and is characterized by osteoporosis, delayed bone age and continuous growth in adulthood, and delayed puberty and multiple ovarian cysts in women. Although mutations in the estrogen receptor β gene ESR2 were found in 46, XY patients with differences of sex development, no genetic...