In: Interactive CardioVascular and Thoracic Surgery, 2016, vol. 22, no. 4, p. 402-405
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In: Glycobiology, 2017, vol. 27, no. 6, p. 525-535
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In: Nanotechnology Reviews, 2017, vol. 6, no. 1, p. 105-110
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In: Nanotechnology Reviews, 2017, vol. 6, no. 1, p. 57-74
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In: Journal of Perinatal Medicine, 2017, vol. 45, no. 7, p. 829-835
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In: Proceedings of the National Academy of Sciences, 2021, vol. 118, no. 10, p. e2017205118
Lipid droplets (LDs) are intracellular organelles responsible for lipid storage, and they emerge from the endoplasmic reticulum (ER) upon the accumulation of neutral lipids, mostly triglycerides (TG), between the two leaflets of the ER membrane. LD biogenesis takes place at ER sites that are marked by the protein seipin, which subsequently recruits additional proteins to catalyze LD formation....
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In: Faraday Discussions, 2020, p. -
Peripheral membrane proteins play a major role in numerous biological processes by transiently associating with cellular membranes, often with extreme membrane specificity. Because of the short-lived nature of these interactions, molecular dynamics (MD) simulations have emerged as an appealing tool to characterize at the structural level the molecular details of the protein-membrane...
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In: Langmuir, 2020, vol. 36, no. 40, p. 11787–11797
We introduce the design and study of a hybrid electrospun membrane with a dedicated nanoscale structural hierarchy for controlled functions in the biomedical domain. The hybrid system comprises submicrometer-sized internally self-assembled lipid nanoparticles (ISAsomes or mesosomes) embedded into the electrospun membrane with a nanofibrous polymer network. The internal structure of ISAsomes, ...
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In: ACS Omega, 2020, vol. 5, no. 38, p. 24724–24732
Cellular delivery of DNA vectors for the expression of therapeutic proteins is a promising approach to treat monogenic disorders or cancer. Significant efforts in a preclinical and clinical setting have been made to develop potent nonviral gene delivery systems based on lipoplexes composed of permanently cationic lipids. However, transfection efficiency and tolerability of such systems are in...
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In: The Journal of Physical Chemistry B, 2020, vol. 124, no. 38, p. 8278–8286
Lipid membranes are indispensable to life, and they regulate countless cellular processes. To investigate the properties of membranes under controlled conditions, numerous reconstitution methods have been developed over the last few decades. Several of these methods result in the formation of lipid bilayers containing residual hydrophobic molecules between the two monolayers. These...
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