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Involvement of long non-coding RNAs in beta cell failure at the onset of type 1 diabetes in NOD mice

Motterle, Anna ; Gattesco, Sonia ; Caille, Dorothée ; Meda, Paolo ; Regazzi, Romano

In: Diabetologia, 2015, vol. 58, no. 8, p. 1827-1835

Pancreatic stone protein/regenerating protein (PSP/reg): a novel secreted protein up-regulated in type 2 diabetes mellitus

Yang, Jiayue ; Li, Ling ; Raptis, Dimitri ; Li, Xiaoshan ; Li, Fengfei ; Chen, Bijun ; He, Jiajia ; Graf, Rolf ; Sun, Zilin

In: Endocrine, 2015, vol. 48, no. 3, p. 856-862

Role of islet microRNAs in diabetes: which model for which question?

Guay, Claudiane ; Regazzi, Romano

In: Diabetologia, 2015, vol. 58, no. 3, p. 456-463

Data mining-based statistical analysis of biological data uncovers hidden significance: clustering Hashimoto's thyroiditis patients based on the response of their PBMC with IL-2 and IFN-γ secretion to stimulation with Hsp60

Tonello, Lucio ; Conway de Macario, Everly ; Marino Gammazza, Antonella ; Cocchi, Massimo ; Gabrielli, Fabio ; Zummo, Giovanni ; Cappello, Francesco ; Macario, Alberto

In: Cell Stress and Chaperones, 2015, vol. 20, no. 2, p. 391-395

Identification of the molecular dysfunction caused by glutamate dehydrogenase S445L mutation responsible for hyperinsulinism/hyperammonemia

Grimaldi, Mariagrazia ; Karaca, Melis ; Latini, Livia ; Brioudes, Estelle ; Schalch, Thomas ; Maechler, Pierre

In: Human Molecular Genetics, 2017, vol. 26, no. 18, p. 3453-3465

GLUT2, glucose sensing and glucose homeostasis

Thorens, Bernard

In: Diabetologia, 2015, vol. 58, no. 2, p. 221-232

Ins1 Cre knock-in mice for beta cell-specific gene recombination

Thorens, Bernard ; Tarussio, David ; Maestro, Miguel ; Rovira, Meritxell ; Heikkilä, Eija ; Ferrer, Jorge

In: Diabetologia, 2015, vol. 58, no. 3, p. 558-565

Inhibition of p38mapk reduces adipose tissue inflammation in aging mediated by arginase-II

Huang, Ji ; Liu, Chang ; Ming, Xiu-Fen ; Yang, Zhihong

In: Pharmacology, 2020, vol. 105, no. 9–10, p. 491–504

Background: Adipose tissue inflammation occurs not only in obesity but also in aging and is mechanistically linked with age-associated diseases. Studies show that ablation of the l-arginine-metabolizing enzyme arginase-II (Arg-II) reduces adipose tissue inflammation and improves glucose tolerance in obesity. However, the role of Arg-II in aging adipose tissue inflammation is not clear....

Effects of the poly(ADP-ribose) polymerase inhibitor olaparib in cerulein-induced pancreatitis

Ahmad, Akbar ; Haas De Mello, Aline ; Szczesny, Bartosz ; Törö, Gábor ; Marcatti, Michela ; Druzhyna, Nadiya ; Liaudet, Lucas ; Tarantini, Stefano ; Salomao, Reinaldo ; Garcia Soriano, Francisco ; Szabo, Csaba

In: Shock, 2020, vol. 53, no. 5, p. 653–665

Objective: Activation of the constitutive nuclear and mitochondrial enzyme poly (ADP- ribose) polymerase (PARP) has been implicated in the pathogenesis of cell dysfunction, inflammation, and organ failure in various forms of critical illness. The objective of our study was to evaluate the efficacy and safety of the clinically approved PARP inhibitor olaparib in an experimental model of...

Platelet transforming growth factor-β1 induces liver sinusoidal endothelial cells to secrete interleukin-6

Balaphas, Alexandre ; Meyer, Jeremy ; Perozzo, Remo ; Zeisser-Labouebe, Magali ; Berndt, Sarah ; Turzi, Antoine ; Fontana, Pierre ; Scapozza, Leonardo ; Gonelle-Gispert, Carmen ; Bühler, Leo H.

In: Cells, 2020, vol. 9, no. 5, p. 1311

The roles and interactions of platelets and liver sinusoidal endothelial cells in liver regeneration are unclear, and the trigger that initiates hepatocyte proliferation is unknown. We aimed to identify the key factors released by activated platelets that induce liver sinusoidal endothelial cells to produce interleukin-6 (IL-6), a cytokine implicated in the early phase of liver regeneration....