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Targeting glycolysis in macrophages confers protection against pancreatic ductal adenocarcinoma

Penny, Hweixian Leong ; Sieow, Je Lin ; Gun, Sin Yee ; Lau, Mai Chan ; Lee, Bernett ; Tan, Jasmine ; Phua, Cindy ; Toh, Florida ; Nga, Yvonne ; Yeap, Wei Hseun ; Janela, Baptiste ; Kumar, Dilip ; Chen, Hao ; Yeong, Joe ; Kenkel, Justin A. ; Pang, Angela ; Lim, Diana ; Toh, Han Chong ; Hon, Tony Lim Kiat ; Johnson, Christopher I. ; Khameneh, Hanif Javanmard ; Mortellaro, Alessandra ; Engleman, Edgar G. ; Rotzschke, Olaf ; Ginhoux, Florent ; Abastado, Jean-Pierre ; Chen, Jinmiao ; Wong, Siew Cheng

In: International journal of molecular sciences, 2021, vol. 22, no. 12, p. 24

Inflammation in the tumor microenvironment has been shown to promote disease progression in pancreatic ductal adenocarcinoma (PDAC); however, the role of macrophage metabolism in promoting inflammation is unclear. Using an orthotopic mouse model of PDAC, we demonstrate that macrophages from tumor-bearing mice exhibit elevated glycolysis. Macrophage- specific deletion of Glucose Transporter 1...

Changes in autopsy rates among cancer patients and their impact on cancer statistics from a public health point of view: a longitudinal study from 1980 to 2010 with data from Cancer Registry Zurich

Bieri, Uwe ; Moch, Holger ; Dehler, Silvia ; Korol, Dimitri ; Rohrmann, Sabine

In: Virchows Archiv, 2015, vol. 466, no. 6, p. 637-643

IL-1 Antagonism in Men With Metabolic Syndrome and Low Testosterone: A Randomized Clinical Trial

Ebrahimi, Fahim ; Urwyler, Sandrine A. ; Straumann, Sven ; Doerpfeld, Simone ; Bernasconi, Luca ; Neyer, Peter ; Schuetz, Philipp ; Mueller, Beat ; Donath, Marc Y. ; Christ-Crain, Mirjam

In: The Journal of Clinical Endocrinology & Metabolism, 2018, vol. 103, no. 9, p. 3466-3476

Interlaboratory variability of MIB1 staining in well-differentiated pancreatic neuroendocrine tumors

Blank, Annika ; Wehweck, Laura ; Marinoni, Ilaria ; Boos, Laura ; Bergmann, Frank ; Schmitt, Anja ; Perren, Aurel

In: Virchows Archiv, 2015, vol. 467, no. 5, p. 543-550

Pancreatic stone protein/regenerating protein (PSP/reg): a novel secreted protein up-regulated in type 2 diabetes mellitus

Yang, Jiayue ; Li, Ling ; Raptis, Dimitri ; Li, Xiaoshan ; Li, Fengfei ; Chen, Bijun ; He, Jiajia ; Graf, Rolf ; Sun, Zilin

In: Endocrine, 2015, vol. 48, no. 3, p. 856-862

Physical Activity and the Frequency of Acute Exacerbations in Patients with Chronic Obstructive Pulmonary Disease

Schönmann, M. ; Sievi, N. ; Clarenbach, C. ; Brack, T. ; Brutsche, M. ; Frey, M. ; Irani, S. ; Leuppi, J. ; Ruediger, J. ; Senn, O. ; Thurnheer, R. ; Kohler, M.

In: Lung, 2015, vol. 193, no. 1, p. 63-70

Off-label use of thoracic aortic endovascular stent grafts to simplify difficult resections and procedures in general thoracic surgery

Walgram, Tanja ; Attigah, Nicolas ; Schwegler, Igor ; Weber, Markus ; Dzemali, Omer ; Berthold, Christian ; Wagnetz, Dirk ; Carboni, Giovanni L.

In: Interactive CardioVascular and Thoracic Surgery, 2018, vol. 26, no. 4, p. 545-550

Preoperative localization of adult nesidioblastosis using 68Ga-DOTA-exendin-4-PET/CT

Christ, Emanuel ; Wild, Damian ; Antwi, Kwadwo ; Waser, Beatrice ; Fani, Melpomeni ; Schwanda, Stefanie ; Heye, Tobias ; Schmid, Christoph ; Baer, Hans ; Perren, Aurel ; Reubi, Jean

In: Endocrine, 2015, vol. 50, no. 3, p. 821-823

The intestinal microbiota: its role in health and disease

Biedermann, Luc ; Rogler, Gerhard

In: European Journal of Pediatrics, 2015, vol. 174, no. 2, p. 151-167

Targeting GLP-1 receptors for repeated magnetic resonance imaging differentiates graded losses of pancreatic beta cells in mice

Vinet, Laurent ; Lamprianou, Smaragda ; Babič, Andrej ; Lange, Norbert ; Thorel, Fabrizio ; Herrera, Pedro ; Montet, Xavier ; Meda, Paolo

In: Diabetologia, 2015, vol. 58, no. 2, p. 304-312