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Université de Fribourg

Initiated by CREB: resolving gene regulatory programs in learning and memory: switch in cofactors and transcription regulators between memory consolidation and maintenance network

Kaldun, Jenifer C. ; Sprecher, Simon G.

In: BioEssays, 2019, vol. 41, no. 8, p. 1900045

Consolidation of long‐term memory is a highly and precisely regulated multistep process. The transcription regulator cAMP response element‐binding protein (CREB) plays a key role in initiating memory consolidation. With time processing, first the cofactors are changed and, secondly, CREB gets dispensable. This ultimately changes the expressed gene program to genes required to maintain the...

Université de Fribourg

The adaptive significance of chromosomal inversion polymorphisms in Drosophila melanogaster

Kapun, Martin ; Flatt, Thomas

In: Molecular Ecology, 2019, vol. 28, no. 6, p. 1263–1282

Chromosomal inversions, structural mutations that reverse a segment of a chromosome, cause suppression of recombination in the heterozygous state. Several studies have shown that inversion polymorphisms can form clines or fluctuate predictably in frequency over seasonal time spans. These observations prompted the hypothesis that chromosomal rearrangements might be subject to spatially and/or ...