In: Angiogenesis, 2015, vol. 18, no. 3, p. 327-345
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In: Human Reproduction Update, 2016, vol. 22, no. 3, p. 382-403
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In: Naunyn-Schmiedeberg's Archives of Pharmacology, 2015, vol. 388, no. 12, p. 1283-1292
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In: Clinical Oral Investigations, 2015, vol. 19, no. 2, p. 385-399
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In: Cellular and Molecular Life Sciences, 2015, vol. 72, no. 15, p. 2793-2808
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In: Pharmacology, 2020, vol. 105, no. 9–10, p. 491–504
Background: Adipose tissue inflammation occurs not only in obesity but also in aging and is mechanistically linked with age-associated diseases. Studies show that ablation of the l-arginine-metabolizing enzyme arginase-II (Arg-II) reduces adipose tissue inflammation and improves glucose tolerance in obesity. However, the role of Arg-II in aging adipose tissue inflammation is not clear....
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In: Frontiers in immunology, 2019, vol. 10, no. 2468, p. 1-11
Somewhat counterintuitively, the tyrosine phosphatase SHP-2 (SH2 domain- containing protein tyrosine phosphatase-2) is crucial for the activation of extracellular signal-regulated kinase (ERK) downstream of various growth factor receptors, thereby exerting essential developmental functions. This phosphatase also deploys proto-oncogenic functions and specific inhibitors have recently been ...
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In: Journal of Cellular Physiology, 2019, p. -
The transient receptor potential melastatin type 8 (TRPM8) receptor channel is expressed in primary afferent neurons where it is the main transducer of innocuous cold temperatures and also in a variety of tumors, where it is involved in progression and metastasis. Modulation of this channel by intracellular signaling pathways has therefore important clinical implications. We investigated the...
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In: Journal of Neurology, 2014, vol. 261, no. 4, p. 732-737
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In: Biological Chemistry, 2015, vol. 396, no. 6-7, p. 813-825
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