In: Communications in Mathematical Physics, 2015, vol. 335, no. 2, p. 609-636
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In: General Relativity and Gravitation, 2015, vol. 47, no. 10, p. 1-19
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In: BIT Numerical Mathematics, 2015, vol. 55, no. 1, p. 33-57
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In: Journal of Infection, 2020, vol. 80, no. 5, p. 578–606
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In: Journal of Antimicrobial Chemotherapy, 2020, vol. 75, no. 12, p. 3593–3600
Background: Carbapenemase-producing Enterobacterales represent a major therapeutic challenge. MBLs, requiring zinc at their catalytic site, could be inhibited by meso-dimercaptosuccinic acid (DMSA), a heavy metal chelator already widely used for treating lead intoxication.Objectives: To evaluate the activity of carbapenems alone or combined with DMSA against MBL-producing Escherichia coli in...
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In: Advanced Functional Materials, 2020, p. 2007706
Transition metal dichalcogenides (TMDs) display a rich variety of instabilities such as spin and charge orders, Ising superconductivity, and topological properties. Their physical properties can be controlled by doping in electric double‐layer field‐effect transistors (FET). However, for the case of single layer NbSe2, FET doping is limited to ≈1 × 1014 cm−2, while a somewhat larger...
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In: Science, 2015, vol. 349, no. 6246, p. 432–436
In eukaryotic cells, phosphatidylserine (PS) is synthesized in the endoplasmic reticulum (ER) but is highly enriched in the plasma membrane (PM), where it contributes negative charge and to specific recruitment of signaling proteins. This distribution relies on transport mechanisms whose nature remains elusive. Here, we found that the PS transporter Osh6p extracted phosphatidylinositol...
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In: Physical Chemistry Chemical Physics, 2015, vol. 17, no. 24, p. 15589–15597
Alpha-synuclein (AS) is a synaptic protein that is directly involved in Parkinson's disease due to its tendency to form protein aggregates. Since AS aggregation can be dependent on the interactions between the protein and the cell plasma membrane, elucidating the membrane binding properties of AS is of crucial importance to establish the molecular basis of AS aggregation into toxic fibrils....
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In: Evolutionary Biology, 2020, p. -
The neck connects the head and the trunk and is the key structure allowing all movements of the head. The neck morphology of birds is the most variable among living tetrapods, including significant differences in the number and shape of the cervical vertebrae. Despite these differences, according to the literature, three morphofunctional regions (i.e., modules) have been identified along the...
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In: Clinical Microbiology and Infection, 2019, vol. 25, no. 12, p. 1563.e5-1563.e8
Colistin often remains the last resort antibiotic active against carbapenemase- producing Enterobacteriaceae. However, while in vitro inoculum effect has been reported, therapeutic relevance of this phenomenon remains questioned.Methods: Ten E. coli strains were used that included the wild-type CFT073 and its transconjugant CFT073-MCR-1 and eight susceptible clinical isolates. Mice with ...
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