In: Bioinformatics, 2016, vol. 32, no. 14, p. 2111-2119
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In: Wiener Medizinische Wochenschrift, 2015, vol. 165, no. 3-4, p. 48-53
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In: Human Molecular Genetics, 2017, vol. 26, no. 3, p. 582-598
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In: Sleep, 2016, vol. 39, no. 3, p. 589-601
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In: International Journal of Legal Medicine, 2015, vol. 129, no. 5, p. 1079-1084
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In: Current Biology, 2020, vol. 30, no. 19, p. 3775-3787.e7
Sphingolipids play important roles in physiology and cell biology, but a systematic examination of their functions is lacking. We performed a genome-wide CRISPRi screen in sphingolipid-depleted human cells and identified hypersensitive mutants in genes of membrane trafficking and lipid biosynthesis, including ether lipid synthesis. Systematic lipidomic analysis showed a coordinate regulation...
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In: PLOS Genetics, 2020, vol. 16, no. 10, p. e1009102
Ryanodine receptors (RyR) are essential regulators of cellular calcium homeostasis and signaling. Vertebrate genomes contain multiple RyR gene isoforms, expressed in different tissues and executing different functions. In contrast, invertebrate genomes contain a single RyR-encoding gene and it has long been proposed that different transcripts generated by alternative splicing may diversify...
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In: The EMBO Journal, 2020, vol. 39, no. 19, p. e103889
Plasticity of the proteome is critical to adapt to varying conditions. Control of mitochondrial protein import contributes to this plasticity. Here, we identified a pathway that regulates mitochondrial protein import by regulated N-terminal processing. We demonstrate that dipeptidyl peptidases 8/9 (DPP8/9) mediate the N-terminal processing of adenylate kinase 2 (AK2) en route to mitochondria....
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In: AIMS biophysics, 2016, vol. 3, no. 4, p. 456-478
The biosynthesis of proteins entails a complex series of chemical reactions that transform the information stored in the nucleic acid sequence into a polypeptide chain that needs to properly fold and reach its functional location in or outside the cell. It is of no surprise that errors might occur that alter the polypeptide sequence leading to a non-functional proteins or that impede delivery...
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In: Biological Chemistry, 2016, vol. 397, no. 9, p. 897-905
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