Consortium of Swiss Academic Libraries

Call for reviews on global health challenges

Yap, Peiling ; Waiswa, Peter ; Berger, Anke ; Künzli, Nino

In: International Journal of Public Health, 2015, vol. 60, no. 7, p. 753-754

Consortium of Swiss Academic Libraries

Erratum to: Global standards for global health in a globalized economy!

Künzli, Nino ; Kutlar Joss, Meltem ; Gintowt, Emily

In: International Journal of Public Health, 2015, vol. 60, no. 8, p. 999-1000

Consortium of Swiss Academic Libraries

Global standards for global health in a globalized economy!

Künzli, Nino ; Joss, Meltem ; Gintowt, Emily

In: International Journal of Public Health, 2015, vol. 60, no. 7, p. 757-759

Università della Svizzera italiana

The antibody response to Plasmodium falciparum : cues for vaccine design and the discovery of receptor-based antibodies

Tan, Joshua ; Piccoli, Luca ; Lanzavecchia, Antonio

In: Annual Review of Immunology

P. falciparum remains a serious public health problem and a continuous challenge for the immune system due to the complexity and diversity of the pathogen. Recent advances from several laboratories in the characterization of the antibody response to the parasite have led to the identification of critical targets for protection and revealed a new mechanism of diversification based on the...

Université de Fribourg

γδ T cells kill Plasmodium falciparum in a granzyme- and granulysin-dependent mechanism during the late blood stage

Hernández-Castañeda, Maria Andrea ; Happ, Katharina ; Cattalani, Filippo ; Wallimann, Alexandra ; Blanchard, Marianne ; Fellay, Isabelle ; Scolari, Brigitte ; Lannes, Nils ; Mbagwu, Smart Ikechukwu ; Fellay, Benoît ; Filgueira, Luis ; Mantel, Pierre-Yves ; Walch, Michael

In: The Journal of Immunology, 2020, vol. 204, no. 7, p. 1798–1809

Plasmodium spp., the causative agent of malaria, have a complex life cycle. The exponential growth of the parasites during the blood stage is responsible for almost all malaria-associated morbidity and mortality. Therefore, tight immune control of the intraerythrocytic replication of the parasite is essential to prevent clinical malaria. Despite evidence that the particular lymphocyte subset ...

Université de Fribourg

Antiplasmodial activity and in vivo bio-distribution of chloroquine molecules released with a 4-(4-ethynylphenyl)-triazole moiety from organometallo-cobalamins

Rossier, Jeremie ; Sovari, Sara Nasiri ; Pavic, Aleksandar ; Vojnovic, Sandra ; Stringer, Tameryn ; Bättig, Sarah ; Smith, Gregory S. ; Nikodinovic-Runic, Jasmina ; Zobi, Fabio

In: Molecules, 2019, vol. 24, no. 12, p. 2310

We have explored the possibility of using organometallic derivatives of cobalamin as a scaffold for the delivery of the same antimalarial drug to both erythro- and hepatocytes. This hybrid molecule approach, intended as a possible tool for the development of multi-stage antimalarial agents, pivots on the preparation of azide- functionalized drugs which, after coupling to the vitamin, are...

Consortium of Swiss Academic Libraries

To e-smoke or not to e-smoke: is that a question?

Künzli, Nino

In: International Journal of Public Health, 2014, vol. 59, no. 5, p. 679-680