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The Mre11-Nbs1 interface is essential for viability and tumor suppression

Kim, Jun Hyun ; Grosbart, Malgorzata ; Anand, Roopesh ; Wyman, Claire ; Cejka, Petr ; Petrini, John H.J.

In: Cell reports, 2017, vol. 18, no. 2, p. 496-507

The Mre11 complex (Mre11, Rad50, and Nbs1) is integral to both DNA repair and ataxia telangiectasia mutated (ATM)-dependent DNA damage signaling. All three Mre11 complex components are essential for viability at the cellular and organismal levels. To delineate essential and non-essential Mre11 complex functions that are mediated by Nbs1, we used TALEN-based genome editing to derive Nbs1...

PI3Kinase signaling in glioblastoma

Lino, M. ; Merlo, A.

In: Journal of Neuro-Oncology, 2011, vol. 103, no. 3, p. 417-427

Comparison of camptothecin derivatives presently in clinical trials: genotoxic potency and mitotic recombination

Cunha, Kênya Silva ; Reguly, Maria Luíza ; Graf, Ulrich ; Rodrigues de Andrade, Heloisa Helena

In: Mutagenesis, 2002, vol. 17, no. 2, p. 141-147

Loss of atm sensitises p53-deficient cells to topoisomerase poisons and antimetabolites

Fedier, A. ; Schlamminger, M. ; Schwarz, V. A. ; Haller, U. ; Howell, S. B. ; Fink, D.

In: Annals of Oncology, 2003, vol. 14, no. 6, p. 938-945

Cleavage of the Bloom's syndrome gene product during apoptosis by caspase-3 results in an impaired interaction with topoisomerase IIIα

Freire, Raimundo ; d'Adda di Fagagna, Fabrizio ; Wu, Leonard ; Pedrazzi, Graziella ; Stagljar, Igor ; Hickson, Ian D. ; Jackson, Stephen P.

In: Nucleic Acids Research, 2001, vol. 29, no. 15, p. 3172-3180

Neoadjuvant bevacizumab and anthracycline-taxane-based chemotherapy in 678 triple-negative primary breast cancers; results from the geparquinto study (GBG 44)†

Gerber, B. ; Loibl, S. ; Eidtmann, H. ; Rezai, M. ; Fasching, P. A. ; Tesch, H. ; Eggemann, H. ; Schrader, I. ; Kittel, K. ; Hanusch, C. ; Kreienberg, R. ; Solbach, C. ; Jackisch, C. ; Kunz, G. ; Blohmer, J. U. ; Huober, J. ; Hauschild, M. ; Nekljudova, V. ; Untch, M. ; von Minckwitz, G.

In: Annals of Oncology, 2013, vol. 24, no. 12, p. 2978-2984

O-161. Modulation of trophoblastic invasion by the endometrium

Bischof, P. ; Tseng, L. ; Campana, A.

In: Human Reproduction, 1997, vol. 12, no. Suppl_2, p. 78-79

Status of p53 in first-trimester cytotrophoblastic cells

Cohen, M. ; Meisser, A. ; Haenggeli, L. ; Irminger-Finger, I. ; Bischof, P.

In: Molecular Human Reproduction, 2007, vol. 13, no. 2, p. 111-116

R-044. Limiting the number of embryos transferred does not significantly influence the outcome of conventional IVF treatment

Berger, E. ; Zakher, S. ; Mueller, M.D. ; Glanzman, P. ; Brandenberger, A. ; Bersinger, N.A. ; Birkhäuser, M.H.

In: Human Reproduction, 1997, vol. 12, no. Suppl_2, p. 255-256

Induction of somatic mutation and recombination by four inhibitors of eukaryotic topoisomerases assayed in the wing spot test of Drosophila melanogaster

Frei, Hansjörg ; Würgler, Friedrich E.

In: Mutagenesis, 1996, vol. 11, no. 4, p. 315-325