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Université de Fribourg

CBX2-dependent transcriptional landscape: implications for human sex development and its defects

Sproll, Patrick ; Eid, Wassim ; Biason-Lauber, Anna

In: Scientific Reports, 2019, vol. 9, no. 1, p. 1–14

Sex development, a complex and indispensable process in all vertebrates, has still not been completely elucidated, although new genes involved in sex development are constantly being discovered and characterized. Chromobox Homolog 2 (CBX2) is one of these new additions and has been identified through a 46,XY girl with double heterozygous variants on CBX2.1, causing Differences of Sex...

Université de Fribourg

Relation of Heart Rate and its Variability during Sleep with Age, Physical Activity, and Body Composition in Young Children

Herzig, David ; Eser, Prisca ; Radtke, Thomas ; Wenger, Alina ; Rusterholz, Thomas ; Wilhelm, Matthias ; Achermann, Peter ; Arhab, Amar ; Jenni, Oskar G. ; Kakebeeke, Tanja H. ; Leeger-Aschmann, Claudia S. ; Messerli-Bürgy, Nadine ; Meyer, Andrea H. ; Munsch, Simone ; Puder, Jardena J. ; Schmutz, Einat A. ; Stülb, Kerstin ; Zysset, Annina E. ; Kriemler, Susi

In: Frontiers in Physiology, 2017, vol. 8, no. 109, p. 1-12

Background: Recent studies have claimed a positive effect of physical activity and body composition on vagal tone. In pediatric populations, there is a pronounced decrease in heart rate with age. While this decrease is often interpreted as an age-related increase in vagal tone, there is some evidence that it may be related to a decrease in intrinsic heart rate. This factor has not been taken into...