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Université de Fribourg

Nonparametric estimation of natural direct and indirect effects based on inverse probability weighting

Huber, Martin ; Yu-Chin, Hsu ; Tsung-Chih, Lai

In: Journal of Econometric Methods, 2019, vol. 8, no. 1, p. 1-20

Using a sequential conditional independence assumption, this paper discusses fully nonparametric estimation of natural direct and indirect causal effects in causal mediation analysis based on inverse probability weighting. We propose estimators of the average indirect effect of a binary treatment, which operates through intermediate variables (or mediators) on the causal path between the...

Université de Fribourg

The Finite Sample Performance of Inference Methods for Propensity Score Matching and Weighting Estimators

Bodory, Hugo ; Camponovo, Lorenzo ; Huber, Martin ; Lechner, Michael

In: Journal of Business and Economic Statistics, 2020, vol. 38, no. 1, p. 183-200

This article investigates the finite sample properties of a range of inference methods for propensity score-based matching and weighting estimators frequently applied to evaluate the average treatment effect on the treated. We analyze both asymptotic approximations and bootstrap methods for computing variances and confidence intervals in our simulation designs, which are based on German...

Université de Fribourg

Bounds on direct and indirect effects under treatment/mediator endogeneity and outcome attrition

Huber, Martin ; Lafférs, Lukáš

(Working Papers SES ; 514)

Causal mediation analysis aims at disentangling a treatment effect into an indirect mechanism operating through an intermediate outcome or mediator, as well as the direct effect of the treatment on the outcome of interest. However, the evaluation of direct and indirect effects is frequently complicated by non-ignorable selection into the treatment and/or mediator, even after controlling for...

Université de Fribourg

Effects of statins to reduce all-cause mortality in heart failure patients: findings from the epical2 cohort study

Al‑Gobari, Muaamar ; Agrinier, Nelly ; Soudant, Marc ; Burnand, Bernard ; Thilly, Nathalie

In: American Journal of Cardiovascular Drugs, 2019, vol. 19, no. 5, p. 497–508

Introduction: The addition of statins to standard care in heart failure (HF) patients remains controversial in clinical practice. Large-scale clinical trials failed to show mortality benefits, but uncertainty persists in real-world settings.Objective: We evaluated whether the prescription of statins at hospital discharge is associated with a reduction in all-cause mortality at up to 1 year of...

Università della Svizzera italiana

Epicutaneous allergen application preferentially boosts specific T cell responses in sensitized patients

Campana, Raffaela ; Moritz, Katharina ; Neubauer, Angela ; Huber, Hans ; Henning, Rainer ; Brodie, Tess M. ; Kaider, Alexandra ; Sallusto, Federica ; Wöhrl, Stefan ; Valenta, Rudolf

In: Scientific reports, 2017, vol. 7, p. 11657

The effects of epicutaneous allergen administration on systemic immune responses in allergic and non-allergic individuals has not been investigated with defined allergen molecules. We studied the effects of epicutaneous administration of rBet v 1 and rBet v 1 fragments on systemic immune responses in allergic and non-allergic subjects. We conducted a clinical trial in which rBet v 1 and two...