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Nerve ultrasound for differentiation between amyotrophic lateral sclerosis and multifocal motor neuropathy

Grimm, Alexander ; Décard, Bernhard ; Athanasopoulou, Ioanna ; Schweikert, Kathi ; Sinnreich, Michael ; Axer, Hubertus

In: Journal of Neurology, 2015, vol. 262, no. 4, p. 870-880

EEF1A1 deacetylation enables transcriptional activation of remyelination

Duman, Mert ; Vaquié, Adrien ; Nocera, Gianluigi ; Heller, Manfred ; Stumpe, Michael ; Sankar, Devanarayanan Siva ; Dengjel, Jörn ; Meijer, Dies ; Yamaguchi, Teppei ; Matthias, Patrick ; Zeis, Thomas ; Schaeren-Wiemers, Nicole ; Hayoz, Antoinette ; Ruff, Sophie ; Jacob, Claire

In: Nature Communications, 2020, vol. 11, no. 1, p. 3420

Remyelination of the peripheral and central nervous systems (PNS and CNS, respectively) is a prerequisite for functional recovery after lesion. However, this process is not always optimal and becomes inefficient in the course of multiple sclerosis. Here we show that, when acetylated, eukaryotic elongation factor 1A1 (eEF1A1) negatively regulates PNS and CNS remyelination. Acetylated eEF1A1...

Parvalbumin expression in oligodendrocyte-like CG4 cells causes a reduction in mitochondrial volume, attenuation in reactive oxygen species production and a decrease in cell processes’ length and branching

Lichvarova, Lucia ; Blum, Walter ; Schwaller, Beat ; Szabolcsi, Viktoria

In: Scientific Reports, 2019, vol. 9, no. 1, p. 10603

Forebrain glial cells - ependymal cells and astrocytes -acquire upon injury- a “reactive” phenotype associated with parvalbumin (PV) upregulation. Since free radicals, e.g. reactive oxygen species (ROS) play a role in the pathogenesis of multiple sclerosis, and that PV-upregulation in glial cells is inversely correlated with the level of oxidative stress, we hypothesized that...

Oligodendroglia in cortical multiple sclerosis lesions decrease with disease progression, but regenerate after repeated experimental demyelination

Rodriguez, Enrique ; Wegner, Christiane ; Kreutzfeldt, Mario ; Neid, Katharina ; Thal, Dietmar ; Jürgens, Tanja ; Brück, Wolfgang ; Stadelmann, Christine ; Merkler, Doron

In: Acta Neuropathologica, 2014, vol. 128, no. 2, p. 231-246

Progressive signaling changes in the olfactory nerve of patients with Alzheimer’s disease

Bathini, Praveen ; Mottas, Antoine ; Jaquet, Muriel ; Brai, Emanuele ; Alberi, Lavinia

In: Neurobiology of Aging, 2019, vol. 76, p. 80–95

Olfaction declines with aging and appears to be a prodromal sign of cognitive decline in progressive neurodegenerative diseases. Nevertheless, very little is known about the pathophysiological changes underlying smell loss that may reflect early network dysfunction. A cross-sectional histoanatomical study was conducted on postmortem olfactory nerves of patients with increasing severity of...

Dynamic Notch signalling regulates neural stem cell state progression in the Drosophila optic lobe

Contreras, Esteban G. ; Egger, Boris ; Gold, Katrina S. ; Brand, Andrea H.

In: Neural Development, 2018, vol. 13, no. 1, p. 25

Neural stem cells generate all of the neurons and glial cells in the central nervous system, both during development and in the adult to maintain homeostasis. In the Drosophila optic lobe, neuroepithelial cells progress through two transient progenitor states, PI and PII, before transforming into neuroblasts. Here we analyse the role of Notch signalling in the transition from neuroepithelial...

Lame Ducks or Fierce Creatures? - The Role of Oligodendrocytes in Multiple Sclerosis

Zeis, T. ; Schaeren-Wiemers, N.

In: Journal of Molecular Neuroscience, 2008, vol. 35, no. 1, p. 91-100

Induction of the members of Notch pathway in superficial basal cell carcinomas treated with imiquimod

Wuest, Maja ; Dummer, Reinhard ; Urosevic, Mirjana

In: Archives of Dermatological Research, 2007, vol. 299, no. 10, p. 493-498

Antigen presentation in autoimmunity and CNS inflammation: how T lymphocytes recognize the brain

Becher, Burkhard ; Bechmann, Ingo ; Greter, Melanie

In: Journal of Molecular Medicine, 2006, vol. 84, no. 7, p. 532-543

Canine distemper virus persistence in demyelinating encephalitis by swift intracellular cell-to-cell spread in astrocytes is controlled by the viral attachment protein

Wyss-Fluehmann, Gaby ; Zurbriggen, Andreas ; Vandevelde, Marc ; Plattet, Philippe

In: Acta Neuropathologica, 2010, vol. 119, no. 5, p. 617-630