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Metabolic insights from zebrafish genetics, physiology, and chemical biology

Schlegel, Amnon ; Gut, Philipp

In: Cellular and Molecular Life Sciences, 2015, vol. 72, no. 12, p. 2249-2260

Université de Fribourg

Inhibition of p38mapk reduces adipose tissue inflammation in aging mediated by arginase-II

Huang, Ji ; Liu, Chang ; Ming, Xiu-Fen ; Yang, Zhihong

In: Pharmacology, 2020, vol. 105, no. 9–10, p. 491–504

Background: Adipose tissue inflammation occurs not only in obesity but also in aging and is mechanistically linked with age-associated diseases. Studies show that ablation of the l-arginine-metabolizing enzyme arginase-II (Arg-II) reduces adipose tissue inflammation and improves glucose tolerance in obesity. However, the role of Arg-II in aging adipose tissue inflammation is not clear....

Université de Fribourg

Body composition-derived BMI cut-offs for overweight and obesity in ethnic Indian and Creole urban children of Mauritius

Ramuth, Harris ; Hunma, Sadhna ; Ramessur, Vinaysing ; Ramuth, Magalutcheemee ; Monnard, Cathriona ; Montani, Jean-Pierre ; Schutz, Yves ; Joonas, Noorjehan ; Dulloo, Abdul G.

In: British Journal of Nutrition, 2020, vol. 124, no. 5, p. 481–492

It is increasingly recognised that the use of BMI cut-off points for diagnosing obesity (OB) and proxy measures for body fatness in a given population needs to take into account the potential impact of ethnicity on the BMI–fat % relationship in order to avoid adiposity status misclassification. This relationship was studied here in 377 Mauritian schoolchildren (200 boys and 177 girls, aged...

Université de Fribourg

How dieting might make some fatter: modeling weight cycling toward obesity from a perspective of body composition autoregulation

Jacquet, Philippe ; Schutz, Yves ; Montani, Jean-Pierre ; Dulloo, Abdul G.

In: International Journal of Obesity, 2020, vol. 44, p. 1243-1253

The notion that dieting makes some people fatter has in the past decade gained considerable interest from both epidemiological predictions and biological plausibility. Several large-scale prospective studies have suggested that dieting to lose weight is associated with future weight gain and obesity, with such predictions being stronger and more consistent among dieters who are in the normal...