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U.S. vaccine and immune globulin product shortages, 2001-15

Ziesenitz, Victoria C. ; Mazer-Amirshahi, Maryann ; Zocchi, Mark S. ; Fox, Erin R. ; May, Larissa S.

In: American Journal of Health-System Pharmacy, 2017, vol. 74, no. 22, p. 1879-1886

Development of broad‐spectrum human monoclonal antibodies for rabies post‐exposure prophylaxis

De Benedictis, Paola ; Minola, Andrea ; Rota Nodari, Elena ; Aiello, Roberta ; Zecchin, Barbara ; Salomoni, Angela ; Foglierini, Mathilde ; Agatic, Gloria ; Vanzetta, Fabrizia ; Lavenir, Rachel ; Lepelletier, Anthony ; Bentley, Emma ; Weiss, Robin ; Cattoli, Giovanni ; Capua, Ilaria ; Sallusto, Federica ; Wright, Edward ; Lanzavecchia, Antonio ; Bourhy, Hervé ; Corti, Davide

In: EMBO molecular medicine, 2016, vol. 8, no. 4, p. 407-421

Currently available rabies post‐exposure prophylaxis (PEP) for use in humans includes equine or human rabies immunoglobulins (RIG). The replacement of RIG with an equally or more potent and safer product is strongly encouraged due to the high costs and limited availability of existing RIG. In this study, we identified two broadly neutralizing human monoclonal antibodies that represent a...

Antigen-specific Th17 cells are primed by distinct and complementary dendritic cell subsets in oropharyngeal candidiasis

Trautwein-Weidner, Kerstin ; Gladiator, André ; Kirchner, Florian R. ; Becattini, Simone ; Rülicke, Thomas ; Sallusto, Federica ; LeibundGut-Landmann, Salomé

In: PLoS pathogens, 2015, vol. 11, no. 10, p. e1005164

Candida spp. can cause severe and chronic mucocutaneous and systemic infections in immunocompromised individuals. Protection from mucocutaneous candidiasis depends on T helper cells, in particular those secreting IL-17. The events regulating T cell activation and differentiation toward effector fates in response to fungal invasion in different tissues are poorly understood. Here we generated...

Heterosubtypic neutralizing antibodies are produced by individuals immunized with a seasonal influenza vaccine

Corti, Davide ; Suguitan Jr., Amorsolo ; Pinna, Debora ; Silacci, Chiara ; Fernandez-Rodriguez, Blanca M. ; Vanzetta, Fabrizia ; Santos, Celia ; Luke, Catherine J. ; Torres-Velez, Fernando J. ; Temperton, Nigel J. ; Weiss, Robin A. ; Sallusto, Federica ; Subbarao, Kanta ; Lanzavecchia, Antonio

In: The Journal of clinical investigation, 2010, vol. 120, no. 5, p. 1663-1673

The target of neutralizing antibodies that protect against influenza virus infection is the viral protein HA. Genetic and antigenic variation in HA has been used to classify influenza viruses into subtypes (H1–H16). The neutralizing antibody response to influenza virus is thought to be specific for a few antigenically related isolates within a given subtype. However, while heterosubtypic...

ATP released by intestinal bacteria limits the generation of protective IgA against enteropathogens

Proietti, Michele ; Perruzza, Lisa ; Scribano, Daniela ; Pellegrini, Giovanni ; D’Antuono, Rocco ; Strati, Francesco ; Raffaelli, Marco ; Gonzalez, Santiago F. ; Thelen, Marcus ; Hardt, Wolf-Dietrich ; Slack, Emma ; Nicoletti, Mauro ; Grassi, Fabio

In: Nature Communications, 2019, vol. 10, p. Art. number: 250

T cell dependent secretory IgA (SIgA) generated in the Peyer’s patches (PPs) of the small intestine shapes a broadly diverse microbiota that is crucial for host physiology. The mutualistic co-evolution of host and microbes led to the relative tolerance of host’s immune system towards commensal microorganisms. The ATP-gated ionotropic P2X7 receptor limits T follicular helper (Tfh) cells...

Toll-like receptors in domestic animals

Jungi, Thomas ; Farhat, Katja ; Burgener, Iwan ; Werling, Dirk

In: Cell and Tissue Research, 2011, vol. 343, no. 1, p. 107-120

Promoting collaboration between livestock and wildlife conservation genetics communities

Joost, Stéphane ; Colli, Licia ; Bonin, Aurélie ; Biebach, Iris ; Allendorf, Fred ; Hoffmann, Irene ; Hanotte, Olivier ; Taberlet, Pierre ; Bruford, Michael

In: Conservation Genetics Resources, 2011, vol. 3, no. 4, p. 785-788

Immunization with DNA vaccines in early life: Advantages and limitations as compared to conventional vaccines

Siegrist, Claire-Anne ; Lambert, Paul-Henri

In: Springer Seminars in Immunopathology, 1997, vol. 19, no. 2, p. 233-243

Antibodies from a DNA peptide vaccination decrease the brain amyloid burden in a mouse model of Alzheimer's disease

Schultz, Jan ; Salzer, Ulrich ; Mohajeri, M. ; Franke, Daniel ; Heinrich, Jochen ; Pavlovic, Jovan ; Wollmer, M. ; Nitsch, Roger ; Moelling, Karin

In: Journal of Molecular Medicine, 2004, vol. 82, no. 10, p. 706-714

Ovine enzootic abortion (OEA): Antibody response in vaccinated sheep compared to naturally infected sheep

Borel, N. ; Sachse, K. ; Rassbach, A. ; Bruckner, L. ; Vretou, E. ; Psarrou, E. ; Pospischil, A.

In: Veterinary Research Communications, 2005, vol. 29, p. 151-156