In: Cancer Causes & Control, 2015, vol. 26, no. 6, p. 881-891
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In: World Journal of Surgery, 2015, vol. 39, no. 1, p. 80-87
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In: World Journal of Surgery, 2015, vol. 39, no. 12, p. 3033-3034
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In: J Epidemiol Community Health, 2020, vol. 74, no. 7, p. 612–616
Public health surveillance is the ongoing systematic collection, analysis and interpretation of data, closely integrated with the timely dissemination of the resulting information to those responsible for preventing and controlling disease and injury. With the rapid development of data science, encompassing big data and artificial intelligence, and with the exponential growth of accessible...
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In: European Journal of Combinatorics, 2020, vol. 87, p. 103098
We tackle the problem of a combinatorial classification of finite metric spaces via their fundamental polytopes, as suggested by Vershik (2010).In this paper we consider a hyperplane arrangement associated to every split pseudometric and, for tree-like metrics, we study the combinatorics of its underlying matroid.- We give explicit formulas for the face numbers of fundamental polytopes and ...
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In: Journal of molecular and genetic medicine, 2013, vol. 7, p. 309-314
The monomer of influenza haemagglutinin is synthesized as a single polypeptide precursor that during maturation is cleaved by proteases into two active subunits. Other studies have demonstrated that the human Transmembrane Protease Serine 2 (TMPRSS2) can cleave the HA of human seasonal influenza viruses. Consequently, we have investigated the use of human Transmembrane Protease Serine 2 to...
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In: Journal of General Internal Medicine, 2014, vol. 29, no. 12, p. 1624-1630
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In: Breast Cancer Research and Treatment, 2014, vol. 143, no. 1, p. 159-169
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In: The Journal of clinical investigation, 2010, vol. 120, no. 5, p. 1663-1673
The target of neutralizing antibodies that protect against influenza virus infection is the viral protein HA. Genetic and antigenic variation in HA has been used to classify influenza viruses into subtypes (H1–H16). The neutralizing antibody response to influenza virus is thought to be specific for a few antigenically related isolates within a given subtype. However, while heterosubtypic...
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In: Molecular & Cellular Proteomics, 2018, vol. 17, no. 10, p. 1909–1921
Seasonal epidemics of influenza A virus are a major cause of severe illness and are of high socio-economic relevance. For the design of effective antiviral therapies, a detailed knowledge of pathways perturbed by virus infection is critical. We performed comprehensive expression and organellar proteomics experiments to study the cellular consequences of influenza A virus infection using three...
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