In: Current Diabetes Reports, 2015, vol. 15, no. 11, p. 1-8
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In: Graefe's Archive for Clinical and Experimental Ophthalmology, 2015, vol. 253, no. 9, p. 1609-1617
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In: Physical Chemistry Chemical Physics, 2015, vol. 17, no. 24, p. 15589–15597
Alpha-synuclein (AS) is a synaptic protein that is directly involved in Parkinson's disease due to its tendency to form protein aggregates. Since AS aggregation can be dependent on the interactions between the protein and the cell plasma membrane, elucidating the membrane binding properties of AS is of crucial importance to establish the molecular basis of AS aggregation into toxic fibrils....
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In: Autophagy, 2019, vol. 15, no. 9, p. 1662–1664
The age-induced deterioration of the organism results in detrimental and ultimately lethal pathologies. The process of aging itself involves a plethora of different mechanisms that should be subverted concurrently to delay and/or prevent age- related maladies. We have identified a natural compound, 4,4ʹ-dimethoxychalcone (DMC), which promotes longevity in yeast, worms and flies, and protects...
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In: Biological Chemistry, 2015, vol. 396, no. 6-7, p. 803-812
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In: The journal of clinical investigation, 2016, vol. 126, no. 3, p. 921-937
Melanoma prognosis is dictated by tumor-infiltrating lymphocytes, the migratory and functional behavior of which is guided by chemokine or cytokine gradients. Here, we retrospectively analyzed the expression patterns of 9 homing receptors (CCR/CXCR) in naive and memory CD4+ and CD8+ T lymphocytes in 57 patients with metastatic melanoma (MMel) with various sites of metastases to evaluate...
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In: Nature Communications, 2019, vol. 10, no. 1, p. 651
Ageing constitutes the most important risk factor for all major chronic ailments, including malignant, cardiovascular and neurodegenerative diseases. However, behavioural and pharmacological interventions with feasible potential to promote health upon ageing remain rare. Here we report the identification of the flavonoid 4,4′- dimethoxychalcone (DMC) as a natural compound with anti-ageing...
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In: Graefe's Archive for Clinical and Experimental Ophthalmology, 2009, vol. 247, no. 9, p. 1165-1171
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In: Graefe's Archive for Clinical and Experimental Ophthalmology, 2006, vol. 244, no. 3, p. 382-389
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In: Graefe's Archive for Clinical and Experimental Ophthalmology, 2005, vol. 243, no. 8, p. 834-836
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