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Université de Fribourg

Poly(ADP-ribose) polymerase inhibition: past, present and future

Curtin, Nicola J. ; Szabo, Csaba

In: Nature Reviews Drug Discovery, 2020, vol. 19, no. 10, p. 711–736

The process of poly(ADP-ribosyl)ation and the major enzyme that catalyses this reaction, poly(ADP-ribose) polymerase 1 (PARP1), were discovered more than 50 years ago. Since then, advances in our understanding of the roles of PARP1 in cellular processes such as DNA repair, gene transcription and cell death have allowed the investigation of therapeutic PARP inhibition for a variety of diseases...

Université de Fribourg

Better roads, better off? : Evidence on improving roads in Tanzania

Dumas, Christelle ; Játiva, Ximena

(Working Papers SES ; 518)

Spatial isolation is considered as one of the main determinants of poverty. Therefore, many transport investments are undertaken with a stated objective of poverty reduction. In our paper, we evaluate a Tanzanian program that rehabilitated 2500km of major roads between 2008 and 2013. We deal with endogenous placement issues with a household fixed-effect strategy combined with a propensity score...

Consortium of Swiss Academic Libraries

Farm management decision and response to climate variability and change in Côte d'Ivoire

Comoé, Hermann ; Finger, Robert ; Barjolle, Dominique

In: Mitigation and Adaptation Strategies for Global Change, 2014, vol. 19, no. 2, p. 123-142