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In vitro evaluation of dual carbapenem combinations against carbapenemase-producing Enterobacteriaceae

Poirel, Laurent ; Kieffer, Nicolas ; Nordmann, Patrice

In: Journal of Antimicrobial Chemotherapy, 2016, vol. 71, no. 1, p. 156-161

Effect of β-lactamase production and β-lactam instability on MIC testing results for Mycobacterium abscessus

Rominski, Anna ; Schulthess, Bettina ; Müller, Daniel M. ; Keller, Peter M. ; Sander, Peter

In: Journal of Antimicrobial Chemotherapy, 2017, vol. 72, no. 11, p. 3070-3078

Efficacy of dual carbapenem treatment in a murine sepsis model of infection due to carbapenemase-producing Acinetobacter baumannii

Cebrero-Cangueiro, T. ; Nordmann, Patrice ; Carretero-Ledesma, M. ; Pachón, J. ; Pachón-Ibáñez, M. E.

In: Journal of Antimicrobial Chemotherapy, 2020, p. dkaa487

Objectives: To evaluate the in vivo efficacy of a dual carbapenem combination containing imipenem plus meropenem against carbapenem-resistant Acinetobacter baumannii producing carbapenemases OXA-23 or OXA-58.Methods: An experimental model of peritonitis using C57BL/6J female mice was developed and the minimum lethal doses were calculated for infections due to OXA-23 or OXA-58 producers of A. ...

Dimercaptosuccinic acid in combination with carbapenems against isogenic strains of Escherichia coli producing or not producing a metallo-β-lactamase in vitro and in murine peritonitis

Cheminet, G. ; de Lastours, V. ; Poirel, Laurent ; Chau, F. ; Peoc’h, K. ; Massias, L. ; Fantin, B. ; Nordmann, Patrice

In: Journal of Antimicrobial Chemotherapy, 2020, vol. 75, no. 12, p. 3593–3600

Background: Carbapenemase-producing Enterobacterales represent a major therapeutic challenge. MBLs, requiring zinc at their catalytic site, could be inhibited by meso-dimercaptosuccinic acid (DMSA), a heavy metal chelator already widely used for treating lead intoxication.Objectives: To evaluate the activity of carbapenems alone or combined with DMSA against MBL-producing Escherichia coli in...

Candida colonization index and subsequent infection in critically ill surgical patients: 20years later

Eggimann, Philippe ; Pittet, Didier

In: Intensive Care Medicine, 2014, vol. 40, no. 10, p. 1429-1448

Efficiency of different control measures for preventing carbapenemase-producing enterobacteria and glycopeptide-resistant Enterococcus faecium outbreaks: a 6-year prospective study in a French multihospital institution, January 2010 to December 2015

Fournier, Sandra ; Desenfant, Laure ; Monteil, Catherine ; Nion-Huang, Michèle ; Richard, Christian ; Jarlier, Vincent ; AP-HP Outbreaks Control Group

In: Eurosurveillance, 2018, vol. 23, no. 8, p. 17–00078

An infection control programme was implemented in a 21,000-bed multihospital institution for controlling the spread of carbapenemase-producing Enterobacteriaceae (CPE) and glycopeptide-resistant Enterococcus faecium (GRE), classified as ‘emergent extensively drug-resistant bacteria’ (eXDR) in France. We evaluated factors associated with outbreaks occurrence (n = 103), which followed 901...

Severe Mycoplasma hominis Infections in Two Renal Transplant Patients

Rohner, P. ; Schnyder, I. ; Ninet, B. ; Schrenzel, J. ; Lew, D. ; Ramla, T. ; Garbino, J. ; Jacomo, V.

In: European Journal of Clinical Microbiology and Infectious Diseases, 2004, vol. 23, no. 3, p. 203-204

Oral nystatin as antifungal prophylaxis in critically ill patients: an old SDD tool to be renewed?

Eggimann, Philippe ; Wolff, Michel ; Garbino, Jorge

In: Intensive Care Medicine, 2005, vol. 31, no. 11, p. 1466-1468

Invasive candidiasis: comparison of management choices by infectious disease and critical care specialists

Eggimann, Philippe ; Calandra, Thierry ; Fluckiger, Ursula ; Bille, Jacques ; Garbino, Jorge ; Glauser, Michel-Pierre ; Marchetti, Oscar ; Ruef, Christian ; Täuber, Martin ; Pittet, Didier

In: Intensive Care Medicine, 2005, vol. 31, no. 11, p. 1514-1521

Community-acquired pneumonia in children aged 2 months to 5 years: application of the WHO guidelines in a developed country setting (Switzerland)

Dirlewanger, Mirjam ; Krahenbuhl, Jean-Daniel ; Fanconi, Sergio ; Vaudaux, Bernard ; Gehri, Mario

In: European Journal of Pediatrics, 2002, vol. 161, no. 8, p. 460-461