Perfeziona i miei risultati

Fast and efficient QTL mapper for thousands of molecular phenotypes

Ongen, Halit ; Buil, Alfonso ; Brown, Andrew Anand ; Dermitzakis, Emmanouil T. ; Delaneau, Olivier

In: Bioinformatics, 2016, vol. 32, no. 10, p. 1479-1485

Visual impairment and progressive phthisis bulbi caused by recessive pathogenic variant in MARK3

Ansar, Muhammad ; Chung, Hyunglok ; Waryah, Yar M. ; Makrythanasis, Periklis ; Falconnet, Emilie ; Rao, Ali Raza ; Guipponi, Michel ; Narsani, Ashok K. ; Fingerhut, Ralph ; Santoni, Federico A. ; Ranza, Emmanuelle ; Waryah, Ali M. ; Bellen, Hugo J. ; Antonarakis, Stylianos E.

In: Human Molecular Genetics, 2018, vol. 27, no. 15, p. 2703-2711

In vivo epigenetic reprogramming of primary human colon cancer cells enhances metastases

Singovski, Grigori ; Bernal, Carolina ; Kuciak, Monika ; Siegl-Cachedenier, Irene ; Conod, Arwen ; Ruiz i Altaba, Ariel

In: Journal of Molecular Cell Biology, 2016, vol. 8, no. 2, p. 157-173

A co-expression gene network associated with developmental regulation of apple fruit acidity

Bai, Yang ; Dougherty, Laura ; Cheng, Lailiang ; Xu, Kenong

In: Molecular Genetics and Genomics, 2015, vol. 290, no. 4, p. 1247-1263

Age-dependent changes in mean and variance of gene expression across tissues in a twin cohort

Viñuela, Ana ; Brown, Andrew A. ; Buil, Alfonso ; Tsai, Pei-Chien ; Davies, Matthew N. ; Bell, Jordana T. ; Dermitzakis, Emmanouil T. ; Spector, Timothy D. ; Small, Kerrin S.

In: Human Molecular Genetics, 2018, vol. 27, no. 4, p. 732-741

MBV: a method to solve sample mislabeling and detect technical bias in large combined genotype and sequencing assay datasets

Fort, Alexandre ; Panousis, Nikolaos I. ; Garieri, Marco ; Antonarakis, Stylianos E. ; Lappalainen, Tuuli ; Dermitzakis, Emmanouil T. ; Delaneau, Olivier ; Stegle, Oliver ; Stegle, Oliver

In: Bioinformatics, 2017, vol. 33, no. 12, p. 1895-1897

Single cell transcriptome atlas of the Drosophila larval brain

Brunet Avalos, Clarisse ; Maier, G. Larisa ; Bruggmann, Rémy ; Sprecher, Simon G.

In: eLife, 2019, vol. 8, p. e50354

Cell diversity of the brain and how it is affected by starvation, remains largely unknown. Here, we introduce a single cell transcriptome atlas of the entire Drosophila first instar larval brain. We first assigned cell-type identity based on known marker genes, distinguishing five major groups: neural progenitors, differentiated neurons, glia, undifferentiated neurons and non-neural cells....

A novel prostate cell type-specific gene signature to interrogate prostate tumor differentiation status and monitor therapeutic response (running title: Phenotypic classification of prostate tumors)

Mapelli, Sarah N. ; Albino, Domenico ; Mello-Grand, Maurizia ; Shinde, Dheeraj ; Scimeca, Manuel ; Bonfiglio, Rita ; Bonanno, Elena ; Chiorino, Giovanna ; Garcia-Escudero, Ramon ; Catapano, Carlo V. ; Carbone, Giuseppina M.

In: Cancers, 2020, vol. 12, no. 1, p. 23 p

In this study, we extracted prostate cell-specific gene sets (metagenes) to define the epithelial differentiation status of prostate cancers and, using a deconvolution-based strategy, interrogated thousands of primary and metastatic tumors in public gene profiling datasets. We identified a subgroup of primary prostate tumors with low luminal epithelial enrichment (LumElow). LumElow tumors were...

Admixture mapping in interspecific Populus hybrids identifies classes of genomic architectures for phytochemical, morphological and growth traits

Bresadola, Luisa ; Caseys, Céline ; Castiglione, Stefano ; Buerkle, C. Alex ; Wegmann, Daniel ; Lexer, Christian

In: New Phytologist, 2019, vol. 223, no. 4, p. 2076–2089

The genomic architecture of functionally important traits is key to understanding the maintenance of reproductive barriers and trait differences when divergent populations or species hybridize. We conducted a genome-wide association study (GWAS) to study trait architecture in natural hybrids of two ecologically divergent Populus species. We genotyped 472 seedlings from a natural hybrid zone...

Evolutionary transcriptomics reveals the origins of olives and the genomic changes associated with their domestication

Gros-Balthazard, Muriel ; Besnard, Guillaume ; Sarah, Gautier ; Holtz, Yan ; Leclercq, Julie ; Santoni, Sylvain ; Wegmann, Daniel ; Glémin, Sylvain ; Khadari, Bouchaib

In: The Plant Journal, 2019, p. tpj.14435

The olive (Olea europaea L. subsp. europaea) is one of the oldest and most socio‐ economically important cultivated perennial crop in the Mediterranean region. Yet, its origins are still under debate and the genetic bases of the phenotypic changes associated with its domestication are unknown. We generated RNA‐sequencing data for 68 wild and cultivated olive trees to study the genetic...