In: Experimental Astronomy, 2015, vol. 39, no. 1, p. 1-10
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In: Clinical Research in Cardiology, 2015, vol. 104, no. 8, p. 656-665
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In: Science, 2015, vol. 349, no. 6246, p. 432–436
In eukaryotic cells, phosphatidylserine (PS) is synthesized in the endoplasmic reticulum (ER) but is highly enriched in the plasma membrane (PM), where it contributes negative charge and to specific recruitment of signaling proteins. This distribution relies on transport mechanisms whose nature remains elusive. Here, we found that the PS transporter Osh6p extracted phosphatidylinositol...
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In: Clinical Microbiology and Infection, 2019, vol. 25, no. 12, p. 1563.e5-1563.e8
Colistin often remains the last resort antibiotic active against carbapenemase- producing Enterobacteriaceae. However, while in vitro inoculum effect has been reported, therapeutic relevance of this phenomenon remains questioned.Methods: Ten E. coli strains were used that included the wild-type CFT073 and its transconjugant CFT073-MCR-1 and eight susceptible clinical isolates. Mice with ...
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In: Cell host & microbe, 2019, vol. 26, no. 5, p. p. 623-637.e8
Potent and broadly neutralizing antibodies (bnAbs) are the hallmark of HIV-1 protection by vaccination. The membrane-proximal external region (MPER) of the HIV-1 gp41 fusion protein is targeted by the most broadly reactive HIV-1 neutralizing antibodies. Here, we examine the structural and molecular mechansims of neutralization by anti-MPER bnAb, LN01, which was isolated from lymph-node-derived...
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In: Cell Metabolism, 2019, vol. 30, no. 2, p. 238–250
The importance of circadian biology has rarely been considered in pre-clinical studies, and even more when translating to the bedside. Circadian biology is becoming a critical factor for improving drug efficacy and diminishing drug toxicity. Indeed, there is emerging evidence showing that some drugs are more effective at nighttime than daytime, whereas for others it is the opposite. This...
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In: Clinical and Translational Oncology, 2014, vol. 16, no. 1, p. 85-90
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In: Clinical Chemistry and Laboratory Medicine (CCLM), 2015, vol. 53, no. 4, p. 583-592
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In: Evolutionary Ecology, 2014, vol. 28, no. 5, p. 869-884
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In: Journal of Clinical Microbiology, 2018, p. -
A rapid test was developed for identification of polymyxin resistance in non-fermenting bacteria. This test detects viable cells after growth in a medium containing a defined concentration of colistin. The principle of this test is based on the visual detection of the reduction of the resazurin reagent, a viability colorant, observed by its color change (blue to purple or pink). Its...
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