In: Antimicrobial Agents and Chemotherapy, 2020, vol. 64, no. 3, p. -
Unlike for classes A and B, a standardized amino acid numbering scheme has not been proposed for the class C (AmpC) β-lactamases, which complicates communication in the field. Here, we propose a scheme developed through a collaborative approach that considers both sequence and structure, preserves traditional numbering of catalytically important residues (Ser64, Lys67, Tyr150, and Lys315),...
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In: Evolution Letters, 2020, vol. 4, no. 2, p. 94–108
Evolutionary processes, including selection, can be indirectly inferred based on patterns of genomic variation among contemporary populations or species. However, this often requires unrealistic assumptions of ancestral demography and selective regimes. Sequencing ancient DNA from temporally spaced samples can inform about past selection processes, as time series data allow direct...
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In: International journal of molecular sciences, 2018, vol. 19, no. 8, p. 2151
The protein ataxin-3 contains a polyglutamine stretch that triggers amyloid aggregation when it is expanded beyond a critical threshold. This results in the onset of the spinocerebellar ataxia type 3. The protein consists of the globular N-terminal Josephin domain and a disordered C-terminal tail where the polyglutamine stretch is located. Expanded ataxin-3 aggregates via a two-stage...
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In: Neuroinformatics, 2011, vol. 9, no. 2-3, p. 279-302
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In: The AAPS Journal, 2008, vol. 10, no. 2, p. 349-359
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In: Protoplasma, 1999, vol. 207, no. 3-4, p. 141-146
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In: JBIC Journal of Biological Inorganic Chemistry, 2010, vol. 15, no. 5, p. 759-776
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In: Acta Geotechnica, 2012, vol. 7, no. 2, p. 139-150
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In: Endocrine, 1997, vol. 6, no. 1, p. 11-19
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In: International Journal of Computer Vision, 2012, vol. 96, no. 1, p. 83-102
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