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Università della Svizzera italiana

Targeting the DNA damage response for patients with lymphoma : preclinical and clinical evidences

Carrassa, Laura ; Colombo, Ilaria ; Damia, Giovanna ; Bertoni, Francesco

In: Cancer treatment reviews, 2020, vol. 90, p. 11

The DNA damage response (DDR) is a well-coordinated cellular network activated by DNA damage. The unravelling of the key players in DDR, their specific inactivation in different tumor types and the synthesis of specific chemical inhibitors of DDR represent a new hot topic in cancer therapy. In this article, we will review the importance of DDR in lymphoma development and how this can be...

Università della Svizzera italiana

Head-to-head comparison of FNA cytology vs. calcitonin measurement in FNA washout fluids (FNA-CT) to diagnose medullary thyroid carcinoma : A systematic review and meta-analysis

Trimboli, Pierpaolo ; Giannelli, Jacopo ; Marques, Bernardo ; Piccardo, Arnoldo ; Crescenzi, Anna ; Deandrea, Maurilio

In: Endocrine, 2022, no. 75, p. 33–39

Purpose: The sensitivity of cytology after fine needle aspiration (FNA-cytology) in detecting medullary thyroid carcinoma (MTC) is low. To overcome this problem, measuring calcitonin (CT) in washout fluid of FNA (FNA-CT) has been largely diffused and showed good performance. However, no evidence-based study exists comparing systematically the sensitivity of FNA-cytology and FNA-CT. This study...

Università della Svizzera italiana

Richter syndrome

Condoluci, Adalgisa ; Rossi, Davide

In: Current Oncology Reports, 2021, vol. 23, no. 3, p. 10

Purpose of Review Richter syndrome (RS) is an uncommon but aggressive evolution of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL). RS is an unmet clinical need in the field of CLL. Recent advances in understanding the biology of this condition provide the rationale for testing new therapeutic concepts in order to improve the outcome of patients developing RS, which is so far...

Università della Svizzera italiana

Impact of COVID-19 on the thyroid gland : an update

Scappaticcio, Lorenzo ; Pitoia, Fabián ; Esposito, Katherine ; Piccardo, Arnoldo ; Trimboli, Pierpaolo

In: Reviews in Endocrine and Metabolic Disorders, 2020, p. 13

Coronavirus disease 2019 (COVID-19) is the pandemic of the new millennium. COVID-19 can cause both pulmonary and systemic inflammation, potentially determining multi-organ dysfunction. Data on the relationship between COVID-19 and thyroid have been emerging, and rapidly increasing since March 2020. The thyroid gland and the virus infection with its associated inflammatory-immune responses are...

Università della Svizzera italiana

The ultrasound risk stratification systems for thyroid nodule have been evaluated against papillary carcinoma : a meta-analysis

Trimboli, Pierpaolo ; Castellana, Marco ; Piccardo, Arnoldo ; Romanelli, Francesco ; Grani, Giorgio ; Giovanella, Luca ; Durante, Cosimo

In: Reviews in endocrine and metabolic disorders, 2020, p. 8 p

Thyroid imaging reporting and data systems (TIRADS) are used to stratify the malignancy risk of thyroid nodule by ultrasound (US) examination. We conducted a meta-analysis to evaluate the pooled cancer prevalence and the relative prevalence of papillary, medullary, follicular thyroid cancer (PTC, MTC, and FTC) and other malignancies among nodules included in studies evaluating their...

Consortium of Swiss Academic Libraries

Surgery Versus Radiotherapy for Early Oropharyngeal Tumors: a Never-Ending Debate

Monnier, Yan ; Simon, Christian

In: Current Treatment Options in Oncology, 2015, vol. 16, no. 9, p. 1-13