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An immature B cell population from peripheral blood serves as surrogate marker for monitoring tumor angiogenesis and anti-angiogenic therapy in mouse models

Fagiani, Ernesta ; Bill, Ruben ; Pisarsky, Laura ; Ivanek, Robert ; Rüegg, Curzio ; Christofori, Gerhard

In: Angiogenesis, 2015, vol. 18, no. 3, p. 327-345

FTY720 and two novel butterfly derivatives exert a general anti-inflammatory potential by reducing immune cell adhesion to endothelial cells through activation of S1P3 and phosphoinositide 3-kinase

Imeri, Faik ; Blanchard, Olivier ; Jenni, Aurelio ; Schwalm, Stephanie ; Wünsche, Christin ; Zivkovic, Aleksandra ; Stark, Holger ; Pfeilschifter, Josef ; Huwiler, Andrea

In: Naunyn-Schmiedeberg's Archives of Pharmacology, 2015, vol. 388, no. 12, p. 1283-1292

CD47 promotes age-associated deterioration in angiogenesis, blood flow and glucose homeostasis

Ghimire, Kedar ; Li, Yao ; Chiba, Takuto ; Julovi, Sohel M. ; Li, Jennifer ; Ross, Mark A. ; Straub, Adam C. ; O’Connell, Philip J. ; Rüegg, Curzio ; Pagano, Patrick J. ; Isenberg, Jeffrey S. ; Rogers, Natasha M.

In: Cells, 2020, vol. 9, no. 7, p. 1695

The aged population is currently at its highest level in human history and is expected to increase further in the coming years. In humans, aging is accompanied by impaired angiogenesis, diminished blood flow and altered metabolism, among others. A cellular mechanism that impinges upon these manifestations of aging can be a suitable target for therapeutic intervention. Here we identify cell...

3-Mercaptopyruvate sulfurtransferase supports endothelial cell angiogenesis and bioenergetics

Abdollahi Govar, Armita ; Törő, Gábor ; Szaniszlo, Peter ; Pavlidou, Athanasia ; Bibli, Sofia‐Iris ; Thanki, Ketan ; Resto, Vicente A. ; Chao, Celia ; Hellmich, Mark R. ; Szabo, Csaba ; Papapetropoulos, Andreas ; Módis, Katalin

In: British Journal of Pharmacology, 2020, vol. 177, no. 4, p. 866–883

During angiogenesis, quiescent endothelial cells (ECs) are activated by various stimuli to form new blood vessels from pre‐existing ones in physiological and pathological conditions. Many research groups have shown that hydrogen sulfide (H2S), the newest member of the gasotransmitter family, acts as a proangiogenic factor. To date, very little is known about the regulatory role of...

ERK phosphorylation and miR-181a expression modulate activation of human memory TH17 cells

Mele, Federico ; Basso, Camilla ; Leoni, Cristina ; Aschenbrenner, Dominik ; Becattini, Simone ; Latorre, Daniela ; Lanzavecchia, Antonio ; Sallusto, Federica ; Monticelli, Silvia

In: Nature communications, 2015, vol. 6, p. 6431

T helper (TH) cell polarization during priming is modulated by a number of signals, but whether polarization to a given phenotype also influences recall responses of memory TH cells is relatively unknown. Here we show that miR-181a is selectively induced in both human and mouse naive T cells differentiating into the TH17, but not TH1 or TH2 subset. In human memory TH17 cells, miR-181a...

MAGI1 mediates eNOS activation and NO production in endothelial cells in response to fluid shear stress

Ghimire, Kedar ; Zaric, Jelena ; Alday-Parejo, Begoña ; Seebach, Jochen ; Bousquenaud, Mélanie ; Stalin, Jimmy ; Bieler, Grégory ; Schnittler, Hans-Joachim ; Rüegg, Curzio

In: Cells, 2019, vol. 8, no. 5, p. 388

Fluid shear stress stimulates endothelial nitric oxide synthase (eNOS) activation and nitric oxide (NO) production through multiple kinases, including protein kinase A (PKA), AMP-activated protein kinase (AMPK), AKT and Ca2+/calmodulin-dependent protein kinase II (CaMKII). Membrane-associated guanylate kinase (MAGUK) with inverted domain structure-1 (MAGI1) is an adaptor protein that...

Amyotrophic lateral sclerosis after embolization of cerebral arterioveneous malformations

Valavanis, Anton ; Schwarz, Urs ; Baumann, Christian ; Weller, Michael ; Linnebank, Michael

In: Journal of Neurology, 2014, vol. 261, no. 4, p. 732-737

Current status of anti-vascular endothelial growth factor therapy in Europe

Wolf, Sebastian

In: Japanese Journal of Ophthalmology, 2008, vol. 52, no. 6, p. 433-439

The Mammary Gland Vasculature Revisited

Andres, Anne-Catherine ; Djonov, Valentin

In: Journal of Mammary Gland Biology and Neoplasia, 2010, vol. 15, no. 3, p. 319-328

Characterization of novel clonal murine endothelial cell lines with an extended life span

Cavallaro, Ugo ; Castelli, Vera ; Perilli, Alessandra ; Dossi, Romina ; Giavazzi, Raffaella ; Pepper, Michael ; Soria, Marco ; Montesano, Roberto

In: In Vitro Cellular & Developmental Biology - Animal, 2000, vol. 36, no. 5, p. 299-308