Perfeziona i miei risultati

Document type

Collection spécifique

Lingua

Université de Fribourg

Bacterial oxidases of the cytochrome bd family : redox enzymes of unique structure, function, and utility as drug targets

Borisov, Vitaliy B. ; Siletsky, Sergey A. ; Paiardini, Alessandro ; Hoogewijs, David ; Forte, Elena ; Giuffrè, Alessandro ; Poole, Robert K.

In: Antioxidants & Redox Signaling, 2021, vol. 34, no. 16, p. 1280-1318

Significance: Cytochrome bd is a ubiquinol:oxygen oxidoreductase of many prokaryotic respiratory chains with a unique structure and functional characteristics. Its primary role is to couple the reduction of molecular oxygen, even at submicromolar concentrations, to water with the generation of a proton motive force used for adenosine triphosphate production. Cytochrome bd is found in many ...

Université de Fribourg

Tissue-specific isoforms of the single C. elegans Ryanodine receptor gene unc-68 control specific functions

Marques, Filipe ; Thapliyal, Saurabh ; Javer, Avelino ; Shrestha, Priyanka ; Brown, André E. X. ; Glauser, Dominique A.

In: PLOS Genetics, 2020, vol. 16, no. 10, p. e1009102

Ryanodine receptors (RyR) are essential regulators of cellular calcium homeostasis and signaling. Vertebrate genomes contain multiple RyR gene isoforms, expressed in different tissues and executing different functions. In contrast, invertebrate genomes contain a single RyR-encoding gene and it has long been proposed that different transcripts generated by alternative splicing may diversify...

Université de Fribourg

Assessing the impact of diagenesis on foraminiferal geochemistry from a low latitude, shallow-water drift deposit

Stainbank, Stephanie ; Spezzaferri, Silvia ; Boever, Eva De ; Bouvier, Anne-Sophie ; Chilcott, Colin ; Leau, Erica S.de ; Foubert, Anneleen ; Kunkelova, Tereza ; Pichevin, Laetitia ; Raddatz, Jacek ; Rüggeberg, Andres ; D.Wright, James ; M.Yu, Siyao ; Zhang, Manlin ; Kroon, Dick

In: Earth and Planetary Science Letters, 2020, vol. 545, p. 116390

Due to their large heat and moisture storage capabilities, the tropics are fundamental in modulating both regional and global climate. Furthermore, their thermal response during past extreme warming periods, such as super interglacials, is not fully resolved. In this regard, we present high-resolution (analytical) foraminiferal geochemical (δ18O and Mg/Ca) records for the last 1800 kyr from...

Université de Fribourg

Inference of natural selection from ancient DNA

Dehasque, Marianne ; Ávila‐Arcos, María C. ; Díez‐del‐Molino, David ; Fumagalli, Matteo ; Guschanski, Katerina ; Lorenzen, Eline D. ; Malaspinas, Anna‐Sapfo ; Marques‐Bonet, Tomas ; Martin, Michael D. ; Murray, Gemma G. R. ; Papadopulos, Alexander S. T. ; Therkildsen, Nina Overgaard ; Wegmann, Daniel ; Dalén, Love ; Foote, Andrew D.

In: Evolution Letters, 2020, vol. 4, no. 2, p. 94–108

Evolutionary processes, including selection, can be indirectly inferred based on patterns of genomic variation among contemporary populations or species. However, this often requires unrealistic assumptions of ancestral demography and selective regimes. Sequencing ancient DNA from temporally spaced samples can inform about past selection processes, as time series data allow direct...