In: Journal of Materials Science: Materials in Medicine, 2015, vol. 26, no. 3, p. 1-8
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In: Journal of Antimicrobial Chemotherapy, 2018, vol. 73, no. 12, p. 3413-3422
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In: European Journal of Clinical Microbiology & Infectious Diseases, 2015, vol. 34, no. 10, p. 2049-2055
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In: The Journal of Clinical Endocrinology & Metabolism, 2018, vol. 103, no. 5, p. 1948-1957
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In: European Journal of Clinical Microbiology & Infectious Diseases, 2015, vol. 34, no. 9, p. 1849-1857
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In: The Journal of Infectious Diseases, 2016, vol. 214, no. 10, p. 1610-1611
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In: Current Infectious Disease Reports, 2015, vol. 17, no. 6, p. 1-5
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In: European Journal of Clinical Microbiology & Infectious Diseases, 2015, vol. 34, no. 3, p. 461-465
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In: Cell, 2016, vol. 166, no. 3, p. 596-608
Influenza virus remains a threat because of its ability to evade vaccine-induced immune responses due to antigenic drift. Here, we describe the isolation, evolution, and structure of a broad-spectrum human monoclonal antibody (mAb), MEDI8852, effectively reacting with all influenza A hemagglutinin (HA) subtypes. MEDI8852 uses the heavy-chain VH6-1 gene and has higher potency and breadth when...
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In: Cell reports, 2020, vol. 32, no. 9, p. 12 p
Multidonor antibodies are of interest for vaccine design because they can in principle be elicited in the general population by a common set of immunogens. For influenza, multidonor antibodies have been observed against the hemagglutinin (HA) stem, but not the immunodominant HA head. Here, we identify and characterize a multidonor antibody class (LPAF-a class) targeting the HA head. This class...
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