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Nuclear translocation of components of the neuronal plasma membrane oxidoreductase after oxidative stress and its effects on induction of apoptosis

Dastoor, Zubin ; Dreyer, Jean-Luc (Dir.) ; Conzelmann, Andreas (Codir.) ; Clarke, Peter G.H. (Codir.)

Thèse de doctorat : Université de Fribourg, 2000 ; Nr, 1293.

The plasma membrane oxidoreductase (PMO) complex may exert important functions in cellular defence mechanism against oxidative stress and in apoptosis. Thus, we aimed to investigate the function of the five proteins GAPDH, Hsc70, enolase γ, aldolase C and Ulip, all of them tightly bound members of a neuronal PMO multi-protein complex, previously isolated and purified from synaptic vesicles and...