Perfeziona i miei risultati

Document type

Collection spécifique

Lingua

Università della Svizzera italiana

Marine anticancer agents : an overview with a particular focus on their chemical classes

Barreca, Marilia ; Spanò, Virginia ; Montalbano, Alessandra ; Cueto, Mercedes ; Díaz Marrero, Ana R. ; Deniz, Irem ; Erdoğan, Ayşegül ; Lukić Bilela, Lada ; Moulin, Corentin ; Taffin-de-Givenchy, Elisabeth ; Spriano, Filippo ; Perale, Giuseppe ; Mehiri, Mohamed ; Rotter, Ana ; Thomas, Olivier P. ; Barraja, Paola ; Gaudêncio, Susana P. ; Bertoni, Francesco

In: Marine drugs, 2020, vol. 18, no. 12, p. 28

The marine environment is a rich source of biologically active molecules for the treatment of human diseases, especially cancer. The adaptation to unique environmental conditions led marine organisms to evolve different pathways than their terrestrial counterparts, thus producing unique chemicals with a broad diversity and complexity. So far, more than 36,000 compounds have been isolated from...

Università della Svizzera italiana

Electrolyte and acid-base disorders triggered by aminoglycoside or colistin therapy : a systematic review

Scoglio, Martin ; Bronz, Gabriel ; Rinoldi, Pietro O. ; Faré, Pietro B. ; Betti, Céline ; Bianchetti, Mario G. ; Simonetti, Giacomo D. ; Gennaro, Viola ; Renzi, Samuele ; Lava, Sebastiano A. G. ; Milani, Gregorio P.

In: Antibiotics, 2021, vol. 10, no. 2, p. 9

Aminoglycoside or colistin therapy may alter the renal tubular function without decreasing the glomerular filtration rate. This association has never been extensively investigated. We conducted a systematic review of the literature following the Preferred Reporting Items for Systematic Reviews and Meta- Analyses recommendations. Databases searched included United States National Library of...

Università della Svizzera italiana

Isonitrile-based multicomponent synthesis of β-amino boronic acids as β-lactamase inhibitors

Bassini, Emanuele ; Gazzotti, Stefano ; Sannio, Filomena ; Lo Presti, Leonardo ; Sgrignani, Jacopo ; Docquier, Jean-Denis ; Grazioso, Giovanni ; Silvani, Alessandra

In: Antibiotics, 2020, vol. 9, no. 5, p. 21 p

The application of various isonitrile-based multicomponent reactions to protected (2-oxoethyl)boronic acid (as the carbonyl component) is described. The Ugi reaction, both in the four components and in the four centers–three components versions, and the van Leusen reaction, proved effective at providing small libraries of MIDA-protected β-aminoboronic acids. The corresponding free...

Università della Svizzera italiana

Multi-targeting bioactive compounds extracted from essential oils as kinase inhibitors

Maruca, Annalisa ; Lanzillotta, Delia ; Rocca, Roberta ; Lupia, Antonio ; Costa, Giosuè ; Catalano, Raffaella ; Moraca, Federica ; Gaudio, Eugenio ; Ortuso, Francesco ; Artese, Anna ; Trapasso, Francesco ; Alcaro, Stefano

In: Molecules, 2020, vol. 25, no. 9, p. 14 p

Essential oils (EOs) are popular in aromatherapy, a branch of alternative medicine that claims their curative effects. Moreover, several studies reported EOs as potential anti- cancer agents by inducing apoptosis in different cancer cell models. In this study, we have considered EOs as a potential resource of new kinase inhibitors with a polypharmacological profile. On the other hand,...

Università della Svizzera italiana

How computational chemistry and drug delivery techniques can support the development of new anticancer drugs

Garofalo, Mariangela ; Grazioso, Giovanni ; Cavalli, Andrea ; Sgrignani, Jacopo

In: Molecules, 2020, vol. 25, no. 7, p. 22 p

The early and late development of new anticancer drugs, small molecules or peptides can be slowed down by some issues such as poor selectivity for the target or poor ADME properties. Computer-aided drug design (CADD) and target drug delivery (TDD) techniques, although apparently far from each other, are two research fields that can give a significant contribution to overcome these problems....

Università della Svizzera italiana

Socioeconomic determinants of regional differences in outpatient antibiotic consumption : evidence from Switzerland

Filippini, Massimo ; Masiero, Giuliano ; Moschetti, Karine

In: Health Policy, 2006, vol. 78, no. 1, p. 77-92

This paper investigates the determinants of regional variations in outpatient antibiotic consumption using Swiss data. The analysis contributes to the debate on appropriate antibiotic use by improving the understanding of its determinants, and may help to define more effective health care policies to reduce the resistance phenomenon. Findings suggest that Switzerland exhibits relatively low...