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Université de Fribourg

OXA-253, a variant of the carbapenem-hydrolyzing class D β-Lactamase OXA-143 in Acinetobacter baumannii

Girlich, Delphine ; Damaceno, Quésia S. ; Oliveira, Adriana Cristina ; Nordmann, Patrice

In: Antimicrobial Agents and Chemotherapy, 2014, vol. 58, no. 5, p. 2976–2978

The carbapenem-hydrolyzing class D β-lactamase OXA-253 was identified in an Acinetobacter baumannii clinical isolate belonging to sequence type 113 (ST113) in Brazil. OXA-253 shares 93.8% amino acid identity with OXA-143. The blaOXA-253 gene is located on a ca. 20-kb plasmid. The genetic environment of the blaOXA-253 gene shares the highest identity with...

Université de Fribourg

Outbreak caused by NDM-1- and RmtB-producing Escherichia coli in Bulgaria

Poirel, Laurent ; Savov, Encho ; Nazli, Arzu ; Trifonova, Angelina ; Todorova, Iva ; Gergova, Ivanka ; Nordmann, Patrice

In: Antimicrobial Agents and Chemotherapy, 2014, vol. 58, no. 4, p. 2472–2474

Twelve consecutive carbapenem-resistant Escherichia coli isolates were recovered from patients (infection or colonization) hospitalized between March and September 2012 in different units at a hospital in Bulgaria. They all produced the carbapenemase NDM-1 and the extended-spectrum-β-lactamase CTX-M-15, together with the 16S rRNA methylase RmtB, conferring high-level resistance to all...

Université de Fribourg

KPC-producing Klebsiella pneumoniae, finally targeting Turkey

Labarca, Jaime ; Poirel, Laurent ; Özdamar, M. ; Turkoglü, S. ; Hakko, E. ; Nordmann, Patrice

In: New Microbes and New Infections, 2014, vol. 2, no. 2, p. 50–51

We report here the first identification of the worldwide spread of Klebsiella pneumoniae carbapenemase-2-producing and carbapenem-resistant K. pneumoniae clone ST258 in Turkey, a country where the distantly-related carbapenemase OXA-48 is known to be endemic. Worryingly, this isolate was also resistant to colistin, now considered to be the last-resort antibiotic for carbapenem-resistant isolates.

Université de Fribourg

Further proofs of concept for the carba NP test

Dortet, Laurent ; Poirel, Laurent ; Nordmann, Patrice

In: Antimicrobial Agents and Chemotherapy, 2014, vol. 58, no. 2, p. 1269–1269

Université de Fribourg

The carbapenemase threat in the animal world : the wrong culprit

Poirel, Laurent ; Stephan, Roger ; Perreten, Vincent ; Nordmann, Patrice

In: Journal of Antimicrobial Chemotherapy, 2014, vol. 69, no. 7, p. 2007-2008

We read with great interest two recent publications dealing with the same topic, i.e. the public health risk related to the occurrence of acquired carbapenemase-producing Gram-negative species in the animal world and the environment.1,2 Woodford et al.1 highlight the series of reports of carbapenemases found either in bacteria isolated from non-human sources or in Salmonella enterica subsp....

Université de Fribourg

Carbapenemase-producing Enterobacteriaceae: Overview of a major public health challenge = Entérobactéries et carbapénémases : bilan et enjeux d’un problème de santé publique majeur

Nordmann, Patrice

In: Médecine et Maladies Infectieuses, 2014, vol. 44, no. 2, p. 51–56

Bacterial resistance to antibiotics has become a major source of concern for public health. Enterobacteriaceae are among the most common human pathogens, causing community-acquired as well as hospital-acquired infections. Carbapenem-resistant Enterobacteriaceae have been increasingly reported worldwide since their first identification more than 20 years ago. Three main classes of carbapenemases...

Université de Fribourg

CarbAcineto NP test for rapid detection of carbapenemase-producers in Acinetobacter spp.

Dortet, Laurent ; Poirel, Laurent ; Errera, Caroline ; Nordmann, Patrice

In: Journal of Clinical Microbiology, 2014, p. JCM.00594–14

Multidrug-resistant Acinetobacter baumannii isolates, and particularly carbapenemase-producing isolates, are increasingly reported worldwide. The biochemically-based Carba NP test, extensively validated for detection of carbapenemase producers among Enterobacteriaceae and Pseudomonas spp., has been modified for the detection of carbapenemase production in Acinetobacter spp. A collection of 151...

Université de Fribourg

Rapid detection of carbapenemase-producing Enterobacteriaceae from blood cultures

Dortet, Laurent ; Bréchard, Ludivine ; Poirel, Laurent ; Nordmann, Patrice

In: Clinical Microbiology and Infection, 2013, p. -

The biochemical-based Carba NP test has been evaluated to detect carbapenemase- producing Enterobacteriaceae (n = 193) directly from spiked blood cultures. It was able to rapidly detect KPC (n = 50), IMP (n = 27), VIM (n = 37), NDM (n = 33) and OXA-48-like producers (n = 46) with sensitivity and specificity of 97.9% and 100%, respectively. This cost-effective technique may be implemented in...

Université de Fribourg

High rate of faecal carriage of extended-spectrum β-lactamase and OXA-48 carbapenemase-producing Enterobacteriaceae at a University hospital in Morocco

Girlich, D. ; Bouihat, N. ; Poirel, L. ; Benouda, A. ; Nordmann, Patrice

In: Clinical Microbiology and Infection, 2013, p. -

Carbapenemase-producing Enterobacteriaceae isolates are being increasingly reported, particularly from countries surrounding the Mediterranean area. We aimed to quantify the prevalence of carbapenemase- and extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae in rectal swabs from hospitalized patients in a University hospital in Morocco, and to compare the performance of three...