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Yeast ribosomal protein L40 assembles late into pre-60S ribosomes and is required for their cytoplasmic maturation

Fernandez-Pevida, Antonio ; Rodriguez-Galan, Olga ; Diaz-Quintana, Antonio ; Kressler, Dieter ; Cruz, Jesus de la

In: Journal of Biological Chemistry, 2012, p. -

Most ribosomal proteins play important roles in ribosome biogenesis and function. Herein, we have examined the contribution of the essential ribosomal protein L40 in these processes in the yeast Saccharomyces cerevisiae. Deletion of either the RPL40A or RPL40B gene and in vivo depletion of L40 impair 60S ribosomal subunit biogenesis. Polysome profile analyses reveal the accumulation of half-mers...