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In Vivo Longitudinal 1H MRS Study of Transgenic Mouse Models of Prion Disease in the Hippocampus and Cerebellum at 14.1T

Cudalbu, Cristina ; Craveiro, Melanie ; Mlynárik, Vladimir ; Bremer, Juliane ; Aguzzi, Adriano ; Gruetter, Rolf

In: Neurochemical Research, 2015, vol. 40, no. 12, p. 2639-2646

A bispecific immunotweezer prevents soluble PrP oligomers and abolishes prion toxicity

Bardelli, Marco ; Frontzek, Karl ; Simonelli, Luca ; Hornemann, Simone ; Pedotti, Mattia ; Mazzola, Federica ; Carta, Manfredi ; Eckhardt, Valeria ; D’Antuono, Rocco ; Virgilio, Tommaso ; González, Santiago F. ; Aguzzi, Adriano ; Varani, Luca

In: Plos pathogens, 2018, vol. 14, no. 10, p. e1007335

Antibodies to the prion protein, PrP, represent a promising therapeutic approach against prion diseases but the neurotoxicity of certain anti-PrP antibodies has caused concern. Here we describe scPOM-bi, a bispecific antibody designed to function as a molecular prion tweezer. scPOM-bi combines the complementarity-determining regions of the neurotoxic antibody POM1 and the neuroprotective...

Sporadic Creutzfeldt-Jakob disease : A comparison of pathological findingsand diffusion weighted imaging

Russmann, Heike ; Vingerhoets, Francois ; Miklossy, Judith ; Maeder, Philippe ; Glatzel, Markus ; Aguzzi, Adriano ; Bogousslavsky, Julien

In: Journal of Neurology, 2005, vol. 252, no. 3, p. 338-342

Current concepts and controversies in prion immunopathology

Heikenwalder, Mathias ; Prinz, Marco ; Heppner, Frank ; Aguzzi, Adriano

In: Journal of Molecular Neuroscience, 2004, vol. 23, no. 1-2, p. 3-11

Heightened incidence of sporadic Creutzfeldt-Jakob disease is associated with a shift in clinicopathological profiles

Stoeck, Katharina ; Hess, Klaus ; Amsler, Lorenz ; Eckert, Tobias ; Zimmermann, Dieter ; Aguzzi, Adriano ; Glatzel, Markus

In: Journal of Neurology, 2008, vol. 255, no. 10, p. 1464-1472

Mice trisomic for a bacterial artificial chromosome with the single-minded 2 gene (Sim2) show phenotypes similar to some of those present in the partial trisomy 16 mouse models of Down syndrome

Chrast, Roman ; Scott, Hamish S. ; Madani, Rime ; Huber, Lars ; Wolfer, David P. ; Prinz, Marco ; Aguzzi, Adriano ; Lipp, Hans-Peter ; Antonarakis, Stylianos E.

In: Human Molecular Genetics, 2000, vol. 9, no. 12, p. 1853-1864

Tissue-specific expression of a FMR1/β-galactosidase fusion gene in transgenic mice

Hergersberg, Martin ; Matsuo, Koichi ; Gassmann, Max ; Schaffner, Walter ; Lüscher, Bernhard ; Rülicke, Thomas ; Aguzzi, Adriano

In: Human Molecular Genetics, 1995, vol. 4, no. 3, p. 359-366

Distal axonopathy in peripheral nerves of PMP22-mutant mice

Sancho, Sara ; Magyar, Josef P. ; Aguzzi, Adriano ; Suter1, Ueli

In: Brain, 1999, vol. 122, no. 8, p. 1563-1577

Bacterial Colitis Increases Susceptibility to Oral Prion Disease

Sigurdson, Christina J. ; Heikenwalder, Mathias ; Manco, Giuseppe ; Barthel, Manja ; Schwarz, Petra ; Stecher, Bärbel ; Krautler, Nike J. ; Hardt, Wolf-Dietrich ; Seifert, Burkhardt ; MacPherson, Andrew J. S. ; Corthesy, Irène ; Aguzzi, Adriano

In: The Journal of Infectious Diseases, 2009, vol. 199, no. 2, p. 243-252

The prion gene is associated with human long-term memory

Papassotiropoulos, Andreas ; Wollmer, M. Axel ; Aguzzi, Adriano ; Hock, Christoph ; Nitsch, Roger M. ; de Quervain, Dominique J.-F

In: Human Molecular Genetics, 2005, vol. 14, no. 15, p. 2241-2246