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Université de Fribourg

Evaluation of three broth microdilution systems to determine colistin susceptibility of Gram-negative bacilli

Jayol, Aurélie ; Nordmann, Patrice ; André, Catherine ; Poirel, Laurent ; Dubois, Véronique

In: Journal of Antimicrobial Chemotherapy, 2018, p. -

The broth microdilution (BMD) method is currently the recommended technique to determine susceptibility to colistin.Objectives: We evaluated the accuracy of three commercialized BMD panels [Sensititre (ThermoFisher Diagnostics), UMIC (Biocentric) and MicroScan (Beckman Coulter)] to determine colistin susceptibility.Methods: A collection of 185 isolates of Gram-negative bacilli (133 colistin...

Université de Fribourg

Plazomicin activity against polymyxin-resistant Enterobacteriaceae, including MCR-1-producing isolates

Denervaud-Tendon, Valérie ; Poirel, Laurent ; Connolly, Lynn E. ; Krause, Kevin M. ; Nordmann, Patrice

In: Journal of Antimicrobial Chemotherapy, 2017, p. -

Objectives: Plazomicin, a novel aminoglycoside with in vitro activity against MDR Gram-negative organisms, is under development to treat patients with serious enterobacterial infections. We evaluated the activity of plazomicin and comparators against colistin-resistant enterobacterial isolates.Methods: Susceptibility to plazomicin and comparators was tested by broth microdilution for a collection...