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Université de Fribourg

A substrate of the ABC transporter PEN3 stimulates bacterial flagellin (flg22)-induced callose deposition in Arabidopsis thaliana

Matern, Andreas ; Böttcher, Christoph ; Eschen-Lippold, Lennart ; Westermann, Bernhard ; Smolka, Ulrike ; Döll, Stefanie ; Trempel, Fabian ; Aryal, Bibek ; Scheel, Dierk ; Geisler, Markus ; Rosahl, Sabine

In: Journal of Biological Chemistry, 2019, vol. 294, no. 17, p. 6857–6870

Nonhost resistance of Arabidopsis thaliana against Phytophthora infestans, a filamentous eukaryotic microbe and the causal agent of potato late blight, is based on a multilayered defense system. Arabidopsis thaliana controls pathogen entry through the penetration-resistance genes PEN2 and PEN3, encoding an atypical myrosinase and an ABC transporter, respectively, required for synthesis and...

Université de Fribourg

Systematic analysis of synergistic proteome modulations in a drug combination of cisplatin and MLN4924

Megger, Dominik Andre ; Abou-Eid, Shadi ; Zülch, Birgit ; Sitek, Barbara

In: Molecular Omics, 2018, vol. 14, no. 6, p. 450–457

Chemotherapeutic treatment regimens often take advantage of synergistic effects of drug combinations. Anticipating that synergistic effects on the cell biological level likely manifest on the proteome level, the analysis of proteome modulations represents an appropriate strategy to study drug combinations on a molecular level. More specifically, the detection of single proteins exhibiting...

Université de Fribourg

Cognitive biases in response to visual body-related stimuli in eating disorders : study protocol for a systematic review and meta-analysis

Schuck, Kathrin ; Munsch, Simone ; Schneider, Silvia

In: Systematic Reviews, 2015, vol. 4, no. 103, p. 2-6

Background: Biased processing of body-related information may be linked to the development and maintenance of eating disorders (ED). The objective of this systematic review will be to examine the occurrence and the extent of cognitive biases in response to visual body-related stimuli in individuals with ED and individuals with an increased risk to develop ED. Methods: Studies will be identified...