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Università della Svizzera italiana

A new constructive heuristic driven by machine learning for the traveling salesman problem

Mele, Umberto Junior ; Gambardella, Luca Maria ; Montemanni, Roberto

In: Algorithms, 2021, vol. 14, no. 9, p. 25

Recent systems applying Machine Learning (ML) to solve the Traveling Salesman Problem (TSP) exhibit issues when they try to scale up to real case scenarios with several hundred vertices. The use of Candidate Lists (CLs) has been brought up to cope with the issues. A CL is defined as a subset of all the edges linked to a given vertex such that it contains mainly edges that are believed to be...

Università della Svizzera italiana

P2X7 receptor restrains pathogenic Tfh cell generation in systemic lupus erythematosus

Faliti, Caterina E. ; Gualtierotti, Roberta ; Rottoli, Elsa ; Gerosa, Maria ; Perruzza, Lisa ; Romagnani, Andrea ; Pellegrini, Giovanni ; De Ponte Conti, Benedetta ; Rossi, Riccardo L. ; Idzko, Marco ; Mazza, Emilia M.C. ; Bicciato, Silvio ; Traggiai, Elisabetta ; Meroni, Pier Luigi ; Grassi, Fabio

In: Journal of Experimental Medicine, 2019, vol. 216, no. 2, p. 317-336

Altered control of T follicular helper (Tfh) cells can lead to generation of autoantibodies and autoimmune manifestations. Signaling pathways that selectively limit pathogenic responses without affecting the protective function of Tfh cells are unknown. Here we show that the ATP-gated ionotropic P2X7 receptor restricts the expansion of aberrant Tfh cells and the generation of self-reactive...

Consortium of Swiss Academic Libraries

Nitinol Carbofilm coated stents for peripheral applications: Study in the porcine model

Prunotto, M. ; Isaia, C. ; Gatti, M. ; Monari, E. ; Pasquino, E. ; Galloni, M.

In: Journal of Materials Science: Materials in Medicine, 2005, vol. 16, no. 12, p. 1231-1238

Consortium of Swiss Academic Libraries

Postmortem chemistry update part I

Palmiere, Cristian ; Mangin, Patrice

In: International Journal of Legal Medicine, 2012, vol. 126, no. 2, p. 187-198