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Università della Svizzera italiana

A novel interaction between the TLR7 and a colchicine derivative revealed through a computational and experimental study

Gentile, Francesco ; Deriu, Marco A. ; Barakat, Khaled ; Danani, Andrea ; Tuszynski, Jack

In: Pharmaceuticals, 2018, vol. 11, no. 1, p. 22

The Toll-Like Receptor 7 (TLR7) is an endosomal membrane receptor involved in the innate immune system response. Its best-known small molecule activators are imidazoquinoline derivatives such as imiquimod (R-837) and resiquimod (R-848). Recently, an interaction between R-837 and the colchicine binding site of tubulin was reported. To investigate the possibility of an interaction between...

Consortium of Swiss Academic Libraries

Changing Face of Vaccination in Immunocompromised Hosts

O'Shea, Daire ; Widmer, Lukas ; Stelling, Jörg ; Egli, Adrian

In: Current Infectious Disease Reports, 2014, vol. 16, no. 9, p. 1-11