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Targeting glycolysis in macrophages confers protection against pancreatic ductal adenocarcinoma

Penny, Hweixian Leong ; Sieow, Je Lin ; Gun, Sin Yee ; Lau, Mai Chan ; Lee, Bernett ; Tan, Jasmine ; Phua, Cindy ; Toh, Florida ; Nga, Yvonne ; Yeap, Wei Hseun ; Janela, Baptiste ; Kumar, Dilip ; Chen, Hao ; Yeong, Joe ; Kenkel, Justin A. ; Pang, Angela ; Lim, Diana ; Toh, Han Chong ; Hon, Tony Lim Kiat ; Johnson, Christopher I. ; Khameneh, Hanif Javanmard ; Mortellaro, Alessandra ; Engleman, Edgar G. ; Rotzschke, Olaf ; Ginhoux, Florent ; Abastado, Jean-Pierre ; Chen, Jinmiao ; Wong, Siew Cheng

In: International journal of molecular sciences, 2021, vol. 22, no. 12, p. 24

Inflammation in the tumor microenvironment has been shown to promote disease progression in pancreatic ductal adenocarcinoma (PDAC); however, the role of macrophage metabolism in promoting inflammation is unclear. Using an orthotopic mouse model of PDAC, we demonstrate that macrophages from tumor-bearing mice exhibit elevated glycolysis. Macrophage- specific deletion of Glucose Transporter 1...

Interlaboratory variability of MIB1 staining in well-differentiated pancreatic neuroendocrine tumors

Blank, Annika ; Wehweck, Laura ; Marinoni, Ilaria ; Boos, Laura ; Bergmann, Frank ; Schmitt, Anja ; Perren, Aurel

In: Virchows Archiv, 2015, vol. 467, no. 5, p. 543-550

High tumor budding stratifies breast cancer with metastatic properties

Salhia, Bodour ; Trippel, Mafalda ; Pfaltz, Katrin ; Cihoric, Nikola ; Grogg, André ; Lädrach, Claudia ; Zlobec, Inti ; Tapia, Coya

In: Breast Cancer Research and Treatment, 2015, vol. 150, no. 2, p. 363-371

Laparoscopic Pancreatic Enucleation With End-to-End Pancreatic Duct Reconstruction

Kokudo, Takashi ; Petermann, David ; Demartines, Nicolas ; Halkic, Nermin

In: Annals of Surgical Oncology, 2015, vol. 22, no. 4, p. 1190-1190

Tumor budding in colorectal cancer revisited: results of a multicenter interobserver study

Koelzer, Viktor ; Zlobec, Inti ; Berger, Martin ; Cathomas, Gieri ; Dawson, Heather ; Dirschmid, Klaus ; Hädrich, Marion ; Inderbitzin, Daniel ; Offner, Felix ; Puppa, Giacomo ; Seelentag, Walter ; Schnüriger, Beat ; Tornillo, Luigi ; Lugli, Alessandro

In: Virchows Archiv, 2015, vol. 466, no. 5, p. 485-493

Was ist neu in der Pathologie neuroendokriner Tumoren des Pankreas? = What is new in the pathology of pancreatic neuroendocrine tumors?

Komminoth, P. ; Perren, A.

In: Der Pathologe, 2015, vol. 36, no. 3, p. 220-228

Towards tailored radiopeptide therapy

Radojewski, Piotr ; Dumont, Rebecca ; Marincek, Nicolas ; Brunner, Philippe ; Mäcke, Helmut ; Müller-Brand, Jan ; Briel, Matthias ; Walter, Martin

In: European Journal of Nuclear Medicine and Molecular Imaging, 2015, vol. 42, no. 8, p. 1231-1237

Morphological and molecular characteristics of HER2 amplified urothelial bladder cancer

Tschui, J. ; Vassella, E. ; Bandi, N. ; Baumgartner, U. ; Genitsch, V. ; Rotzer, D. ; Seiler, R. ; Thalmann, G. ; Fleischmann, A.

In: Virchows Archiv, 2015, vol. 466, no. 6, p. 703-710

Magi1, a new potential tumor suppressor gene in estrogen receptor positive breast cancer

Alday-Parejo, Begoña ; Richard, François ; Wörthmüller, Janine ; Rau, Tilman ; Galván, José A. ; Desmedt, Christine ; Santamaria-Martinez, Albert ; Rüegg, Curzio

In: Cancers, 2020, vol. 12, no. 1, p. 223

Membrane-associated guanylate kinase (MAGUK) with inverted domain structure-1 (MAGI1) is an intracellular adaptor protein that stabilizes epithelial junctions consistent with a tumor suppressive function in several cancers of epithelial origin. Here we report, based on experimental results and human breast cancer (BC) patients’ gene expression data, that MAGI1 is highly expressed and acts...

Expression analysis of heat shock protein 90 (HSP90) and Her2 in colon carcinoma

Drecoll, Enken ; Nitsche, Ulrich ; Bauer, Karina ; Berezowska, Sabina ; Slotta-Huspenina, Julia ; Rosenberg, Robert ; Langer, Rupert

In: International Journal of Colorectal Disease, 2014, vol. 29, no. 6, p. 663-671