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Université de Fribourg

Multiple neurons encode CrebB dependent appetitive long-term memory in the mushroom body circuit

Widmer, Yves F. ; Fritsch, Cornelia ; Jungo, Magali M. ; Almeida, Silvia ; Egger, Boris ; Sprecher, Simon G.

In: eLife, 2018, vol. 7, p. e39196

Lasting changes in gene expression are critical for the formation of long-term memories (LTMs), depending on the conserved CrebB transcriptional activator. While requirement of distinct neurons in defined circuits for different learning and memory phases have been studied in detail, only little is known regarding the gene regulatory changes that occur within these neurons. We here use the...