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Université de Fribourg

Effects of anti-PD-1 immunotherapy on tumor regression: insights from a patient-derived xenograft model

Martín-Ruiz, Asunción ; Fiuza-Luces, Carmen ; Martínez-Martínez, Esther ; Arias, Clemente F. ; Gutiérrez, Lourdes ; Ramírez, Manuel ; Martín-Acosta, Paloma ; Coronado, Maria José ; Lucia, Alejandro ; Provencio, Mariano

In: Scientific Reports, 2020, vol. 10, no. 1, p. 7078

Immunotherapies, such as checkpoint blockade of programmed cell death protein-1 (PD-1), have resulted in unprecedented improvements in survival for patients with lung cancer. Nonetheless, not all patients benefit equally and many issues remain unresolved, including the mechanisms of action and the possible effector function of immune cells from non-lymphoid lineages. The purpose of this...

Université de Fribourg

Permafrost is warming at a global scale

Biskaborn, Boris K. ; Smith, Sharon L. ; Noetzli, Jeannette ; Matthes, Heidrun ; Vieira, Gonçalo ; Streletskiy, Dmitry A. ; Schoeneich, Philippe ; Romanovsky, Vladimir E. ; Lewkowicz, Antoni G. ; Abramov, Andrey ; Allard, Michel ; Boike, Julia ; Cable, William L. ; Christiansen, Hanne H. ; Delaloye, Reynald ; Diekmann, Bernhard ; Drozdov, Dmitry ; Etzelmüller, Bernd ; Grosse, Guido ; Guglielmin, Mauro ; Ingeman-Nielsen, Thomas ; Isaksen, Ketil ; Ishikawa, Mamoru ; Johansson, Margareta ; Johannsson, Halldor ; Joo, Anseok ; Kaverin, Dmitry ; Kholodov, Alexander ; Konstantinov, Pavel ; Kröger, Tim ; Lambiel, Christophe ; Lanckman, Jean-Pierre ; Luo, Dongliang ; Malkova, Galina ; Meiklejohn, Ian ; Moskalenko, Natalia ; Oliva, Marc ; Phillips, Marcia ; Ramos, Miguel ; Sannel, A. Britta K. ; Sergeev, Dmitrii ; Seybold, Cathy ; Skryabin, Pavel ; Vasiliev, Alexander ; Wu, Qingbai ; Yoshikawa, Kenji ; Zheleznyak, Mikhail ; Lantuit, Hugues

In: Nature Communications, 2019, vol. 10, no. 1, p. 264

Permafrost warming has the potential to amplify global climate change, because when frozen sediments thaw it unlocks soil organic carbon. Yet to date, no globally consistent assessment of permafrost temperature change has been compiled. Here we use a global data set of permafrost temperature time series from the Global Terrestrial Network for Permafrost to evaluate temperature change across...