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The Effect of Wound Dressings on a Bio-Engineered Human Dermo-Epidermal Skin Substitute in a Rat Model

Hüging, Martina ; Biedermann, Thomas ; Sobrio, Monia ; Meyer, Sarah ; Böttcher-Haberzeth, Sophie ; Manuel, Edith ; Horst, Maya ; Hynes, Sally ; Reichmann, Ernst ; Schiestl, Clemens ; Hartmann-Fritsch, Fabienne

In: Journal of Burn Care & Research, 2017, vol. 38, no. 6, p. 354-364

6-Thioguanine-loaded polymeric micelles deplete myeloid-derived suppressor cells and enhance the efficacy of T cell immunotherapy in tumor-bearing mice

Jeanbart, Laura ; Kourtis, Iraklis ; van der Vlies, André ; Swartz, Melody ; Hubbell, Jeffrey

In: Cancer Immunology, Immunotherapy, 2015, vol. 64, no. 8, p. 1033-1046

Primary wound closure with a Limberg flap vs. secondary wound healing after excision of a pilonidal sinus: a multicentre randomised controlled study

Käser, S. ; Zengaffinen, R. ; Uhlmann, M. ; Glaser, C. ; Maurer, C.

In: International Journal of Colorectal Disease, 2015, vol. 30, no. 1, p. 97-103

Long-term expression pattern of melanocyte markers in light- and dark-pigmented dermo-epidermal cultured human skin substitutes

Biedermann, Thomas ; Klar, Agnieszka ; Böttcher-Haberzeth, Sophie ; Michalczyk, Teresa ; Schiestl, Clemens ; Reichmann, Ernst ; Meuli, Martin

In: Pediatric Surgery International, 2015, vol. 31, no. 1, p. 69-76

Nanofat Grafting for Scar Treatment and Skin Quality Improvement

Uyulmaz, Semra ; Sanchez Macedo, Nadia ; Rezaeian, Farid ; Giovanoli, Pietro ; Lindenblatt, Nicole

In: Aesthetic Surgery Journal, 2018, vol. 38, no. 4, p. 421-428

Formation and role of exosomes in cancer

Brinton, Lindsey ; Sloane, Hillary ; Kester, Mark ; Kelly, Kimberly

In: Cellular and Molecular Life Sciences, 2015, vol. 72, no. 4, p. 659-671

Distal and proximal hypoxia response elements cooperate to regulate organ-specific erythropoietin gene expression

Orlando, Ilaria M. C. ; Lafleur, Véronique N. ; Storti, Federica ; Spielmann, Patrick ; Crowther, Lisa ; Santambrogio, Sara ; Schödel, Johannes ; Hoogewijs, David ; Mole, David R. ; Wenger, Roland H.

In: Haematologica, 2019, vol. 105, no. 12, p. 2774–2784

While it is well-established that distal hypoxia response elements (HREs) regulate hypoxia-inducible factor (HIF) target genes such as erythropoietin (Epo), an interplay between multiple distal and proximal (promoter) HREs has not been described so far. Hepatic Epo expression is regulated by a HRE located downstream of the EPO gene, but this 3' HRE is dispensable for renal EPO gene...

Hypoxia pathway proteins are master regulators of erythropoiesis

Watts, Deepika ; Gaete, Diana ; Rodriguez, Diego ; Hoogewijs, David ; Rauner, Martina ; Sormendi, Sundary ; Wielockx, Ben

In: International Journal of Molecular Sciences, 2020, vol. 21, no. 21, p. 8131

Erythropoiesis is a complex process driving the production of red blood cells. During homeostasis, adult erythropoiesis takes place in the bone marrow and is tightly controlled by erythropoietin (EPO), a central hormone mainly produced in renal EPO- producing cells. The expression of EPO is strictly regulated by local changes in oxygen partial pressure (pO2) as under-deprived oxygen (hypoxia);...

Proteomic profiling of fibroblasts isolated from chronic wounds identifies disease-relevant signaling pathways

Berberich, Bettina ; Thriene, Kerstin ; Gretzmeier, Christine ; Kühl, Tobias ; Bayer, Hans ; Athanasiou, Ioannis ; Rafei-Shamsabadi, David Ali ; Bruckner-Tuderman, Leena ; Nyström, Alexander ; Kiritsi, Dimitra ; Dengjel, Jörn

In: Journal of Investigative Dermatology, 2020, vol. 140, no. 11, p. 2280-2290.e4

Chronic skin wounds accompany many prevalent age-related diseases and are a major cause of morbidity and mortality. Both keratinocytes and fibroblasts contribute to the pathomechanisms in chronic skin wounds. Dysregulated pathways in the epidermis have been extensively studied, but little is known of the influence of dermal fibroblasts on chronic wounding. We isolated fibroblasts from chronic...

The Pseudomonas aeruginosa lectin LecB causes integrin internalization and inhibits epithelial wound healing

Thuenauer, Roland ; Landi, Alessia ; Trefzer, Anne ; Altmann, Silke ; Wehrum, Sarah ; Eierhoff, Thorsten ; Diedrich, Britta ; Dengjel, Jörn ; Nyström, Alexander ; Imberty, Anne ; Römer, Winfried

In: mBio, 2020, vol. 11, no. 2, p. -

The opportunistic bacterium Pseudomonas aeruginosa produces the fucose- specific lectin LecB, which has been identified as a virulence factor. LecB has a tetrameric structure with four opposing binding sites and has been shown to act as a cross-linker. Here, we demonstrate that LecB strongly binds to the glycosylated moieties of β1-integrins on the basolateral plasma membrane of epithelial...