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Highly Dynamic Spatiotemporal Organization of Low-Frequency Activities During Behavioral States in the Mouse Cerebral Cortex

Fernandez, Laura M J. ; Comte, Jean-Christophe ; Le Merre, Pierre ; Lin, Jian-Sheng ; Salin, Paul-A ; Crochet, Sylvain

In: Cerebral Cortex, 2017, vol. 27, no. 12, p. 5444-5462

Dietary potassium and the renal control of salt balance and blood pressure

Penton, David

In: Pflügers Archiv : European Journal of Physiology, ///-

N-acetylcysteine in a Double-Blind Randomized Placebo-Controlled Trial: Toward Biomarker-Guided Treatment in Early Psychosis

Conus, Philippe ; Seidman, Larry J. ; Fournier, Margot ; Xin, Lijing ; Cleusix, Martine ; Baumann, Philipp S. ; Ferrari, Carina ; Cousins, Ann ; Alameda, Luis ; Gholam-Rezaee, Mehdi ; Golay, Philippe ; Jenni, Raoul ; Woo, T -U Wilson ; Keshavan, Matcheri S. ; Eap, Chin B. ; Wojcik, Joanne ; Cuenod, Michel ; Buclin, Thierry ; Gruetter, Rolf ; Do, Kim Q.

In: Schizophrenia Bulletin, 2018, vol. 44, no. 2, p. 317-327

Genetic Polymorphism Associated Prefrontal Glutathione and Its Coupling With Brain Glutamate and Peripheral Redox Status in Early Psychosis

Xin, Lijing ; Mekle, Ralf ; Fournier, Margot ; Baumann, Philipp S. ; Ferrari, Carina ; Alameda, Luis ; Jenni, Raoul ; Lu, Huanxiang ; Schaller, Benoit ; Cuenod, Michel ; Conus, Philippe ; Gruetter, Rolf ; Do, Kim Q.

In: Schizophrenia Bulletin, 2016, vol. 42, no. 5, p. 1185-1196

Comparison of Sleep Disorders between Real and Simulated 3,450-m Altitude

Heinzer, Raphaël ; Saugy, Jonas J. ; Rupp, Thomas ; Tobback, Nadia ; Faiss, Raphael ; Bourdillon, Nicolas ; Rubio, José Haba ; Millet, Grégoire P.

In: Sleep, 2016, vol. 39, no. 8, p. 1517-1523

Distal and proximal hypoxia response elements cooperate to regulate organ-specific erythropoietin gene expression

Orlando, Ilaria M. C. ; Lafleur, Véronique N. ; Storti, Federica ; Spielmann, Patrick ; Crowther, Lisa ; Santambrogio, Sara ; Schödel, Johannes ; Hoogewijs, David ; Mole, David R. ; Wenger, Roland H.

In: Haematologica, 2019, vol. 105, no. 12, p. 2774–2784

While it is well-established that distal hypoxia response elements (HREs) regulate hypoxia-inducible factor (HIF) target genes such as erythropoietin (Epo), an interplay between multiple distal and proximal (promoter) HREs has not been described so far. Hepatic Epo expression is regulated by a HRE located downstream of the EPO gene, but this 3' HRE is dispensable for renal EPO gene...

Meta-analysis of metabolites involved in bioenergetic pathways reveals a pseudohypoxic state in Down syndrome

Pecze, Laszlo ; Randi, Elisa B. ; Szabo, Csaba

In: Molecular Medicine, 2020, vol. 26, no. 1, p. 102

Clinical observations and preclinical studies both suggest that Down syndrome (DS) may be associated with significant metabolic and bioenergetic alterations. However, the relevant scientific literature has not yet been systematically reviewed. The aim of the current study was to conduct a meta-analysis of metabolites involved in bioenergetics pathways in DS to conclusively determine the...

Hypoxia pathway proteins are master regulators of erythropoiesis

Watts, Deepika ; Gaete, Diana ; Rodriguez, Diego ; Hoogewijs, David ; Rauner, Martina ; Sormendi, Sundary ; Wielockx, Ben

In: International Journal of Molecular Sciences, 2020, vol. 21, no. 21, p. 8131

Erythropoiesis is a complex process driving the production of red blood cells. During homeostasis, adult erythropoiesis takes place in the bone marrow and is tightly controlled by erythropoietin (EPO), a central hormone mainly produced in renal EPO- producing cells. The expression of EPO is strictly regulated by local changes in oxygen partial pressure (pO2) as under-deprived oxygen (hypoxia);...

Compartment and cell-type specific hypoxia responses in the developing Drosophila brain

Baccino-Calace, Martin ; Prieto, Daniel ; Cantera, Rafael ; Egger, Boris

In: Biology Open, 2020, vol. 9, no. 8, p. -

Environmental factors such as the availability of oxygen are instructive cues that regulate stem cell maintenance and differentiation. We used a genetically encoded biosensor to monitor the hypoxic state of neural cells in the larval brain of Drosophila. The biosensor reveals brain compartment and cell-type specific levels of hypoxia. The values correlate with differential tracheolation that...

Hypoxia enhances endothelial intercellular adhesion molecule 1 protein level through upregulation of arginase type II and mitochondrial oxidative stress

Liang, Xiujie ; Arullampalam, Prakash ; Yang, Zhihong ; Ming, Xiu-Fen

In: Frontiers in Physiology, 2019, vol. 10, p. -

Hypoxia plays a crucial role in the pathogenesis of cardiovascular diseases. Mitochondrial enzyme arginase type II (Arg-II) is reported to lead to endothelial dysfunction and enhance the expression of endothelial inflammatory adhesion molecules such as intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1). In this study, we investigate the role of Arg-II in...