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Université de Fribourg

Albumin evokes Ca 2+ -induced cell oxidative stress and apoptosis through TRPM2 channel in renal collecting duct cells reduced by curcumin

Nazıroğlu, Mustafa ; Çiğ, Bilal ; Yazğan, Yener ; Schwaerzer, Gerburg K. ; Theilig, Franziska ; Pecze, László

In: Scientific Reports, 2019, vol. 9, no. 1, p. 1–16

In proteinuric nephropathies of chronic kidney disease, the epithelial cells of the nephron including the collecting duct are exposed to high concentrations of luminal albumin. Albumin is taken up from collecting duct cells by endocytosis causing excessive reactive oxygen species (ROS) production and a proinflammatory response. Curcumin used in the traditional medicine possesses...

Università della Svizzera italiana

Transgenic expression of human signal regulatory protein alpha in Rag2−/−γc −/− mice improves engraftment of human hematopoietic cells in humanized mice

Strowig, Till ; Rongvaux, Anthony ; Rathinam, Chozhavendan ; Takizawa, Hitoshi ; Borsotti, Chiara ; Philbrick, William ; Eynon, Elizabeth E. ; Manz, Markus G. ; Flavell, Richard A.

In: Proceedings of the national academy of sciences of the United States of America, 2011, vol. 108, no. 32, p. 13218-13223

Transplantation of human hematopoietic stem cells into severely immunocompromised newborn mice allows the development of a human hematopoietic and immune system in vivo. NOD/scid/γc−/− (NSG) and BALB/c Rag2−/ −γc−/− mice are the most commonly used mouse strains for this purpose and a number of studies have demonstrated the high value of these model systems in areas spanning from...

Université de Fribourg

Increased temperature disrupts the biodiversity–ecosystem functioning relationship

Parain, Elodie C. ; Rohr, Rudolf P. ; Gray, Sarah M. ; Bersier, Louis-Félix

In: The American Naturalist, 2018, vol. 193, no. 2, p. 227–239

Gaining knowledge of how ecosystems provide essential services to humans is of primary importance, especially with the current threat of climate change. Yet little is known about how increased temperature will impact the biodiversity–ecosystem functioning (BEF) relationship. We tackled this subject theoretically and experimentally. We developed a BEF theory based on mechanistic population ...