Affiner les résultats

Parkin functionally interacts with PGC-1α to preserve mitochondria and protect dopaminergic neurons

Zheng, Lu ; Bernard-Marissal, Nathalie ; Moullan, Norman ; D'Amico, Davide ; Auwerx, Johan ; Moore, Darren J. ; Knott, Graham ; Aebischer, Patrick ; Schneider, Bernard L.

In: Human Molecular Genetics, 2017, vol. 26, no. 3, p. 582-598

A subcutaneous cellular implant for passive immunization against amyloid-β reduces brain amyloid and tau pathologies

Lathuilière, Aurélien ; Laversenne, Vanessa ; Astolfo, Alberto ; Kopetzki, Erhard ; Jacobsen, Helmut ; Stampanoni, Marco ; Bohrmann, Bernd ; Schneider, Bernard L. ; Aebischer, Patrick

In: Brain, 2016, vol. 139, no. 5, p. 1587-1604

Absence of parvalbumin increases mitochondria volume and branching of dendrites in inhibitory Pvalb neurons in vivo: a point of convergence of autism spectrum disorder (ASD) risk gene phenotypes

Janickova, Lucia ; Rechberger, Karin Farah ; Wey, Lucas ; Schwaller, Beat

In: Molecular Autism, 2020, vol. 11, no. 1, p. 47

In fast firing, parvalbumin (PV)-expressing (Pvalb) interneurons, PV acts as an intracellular Ca2+ signal modulator with slow-onset kinetics. In Purkinje cells of PV−/− mice, adaptive/homeostatic mechanisms lead to an increase in mitochondria, organelles equally capable of delayed Ca2+ sequestering/buffering. An inverse regulation of PV and mitochondria likewise operates in cell model...

Peripheral administration of tau aggregates triggers intracerebral tauopathy in transgenic mice

Clavaguera, Florence ; Hench, Jürgen ; Lavenir, Isabelle ; Schweighauser, Gabriel ; Frank, Stephan ; Goedert, Michel ; Tolnay, Markus

In: Acta Neuropathologica, 2014, vol. 127, no. 2, p. 299-301

High baseline BDNF serum levels and early psychopathological improvement are predictive of treatment outcome in major depression

Mikoteit, Thorsten ; Beck, Johannes ; Eckert, Anne ; Hemmeter, Ulrich ; Brand, Serge ; Bischof, Roland ; Holsboer-Trachsler, Edith ; Delini-Stula, Alexandra

In: Psychopharmacology, 2014, vol. 231, no. 15, p. 2955-2965

The mitochondrial unfolded protein response in mammalian physiology

Mottis, Adrienne ; Jovaisaite, Virginija ; Auwerx, Johan

In: Mammalian Genome, 2014, vol. 25, no. 9-10, p. 424-433

Progressive signaling changes in the olfactory nerve of patients with Alzheimer’s disease

Bathini, Praveen ; Mottas, Antoine ; Jaquet, Muriel ; Brai, Emanuele ; Alberi, Lavinia

In: Neurobiology of Aging, 2019, vol. 76, p. 80–95

Olfaction declines with aging and appears to be a prodromal sign of cognitive decline in progressive neurodegenerative diseases. Nevertheless, very little is known about the pathophysiological changes underlying smell loss that may reflect early network dysfunction. A cross-sectional histoanatomical study was conducted on postmortem olfactory nerves of patients with increasing severity of...

Parvalbumin alters mitochondrial dynamics and affects cell morphology

Lichvarova, Lucia ; Henzi, Thomas ; Safiulina, Dzhamilja ; Kaasik, Allen ; Schwaller, Beat

In: Cellular and Molecular Life Sciences, 2018, vol. 75, no. 24, p. 4643–4666

The Ca2+-binding protein parvalbumin (PV) and mitochondria play important roles in Ca2+ signaling, buffering and sequestration. Antagonistic regulation of PV and mitochondrial volume is observed in in vitro and in vivo model systems. Changes in mitochondrial morphology, mitochondrial volume and dynamics (fusion, fission, mitophagy) resulting from modulation of PV were investigated in MDCK...

Modelling protein-protein interactions to elucidate molecular mechanisms behind neurodegenerative diseases

Grasso, Gianvito ; Krause, Rolf (Dir.) ; Danani, Andrea (Codir.)

Thèse de doctorat : Università della Svizzera italiana, 2018 ; 2018INFO017.

The worldwide significant increase in life expectancy has recently drawn the attention of the scientific community to neurodegenerative pathologies of the elderly population. These neurodegenerative disorders arise from the abnormal protein aggregation in the nervous tissue leading to intracellular inclusions or extracellular aggregates in specific brain areas. A feasible strategy to prevent...

Regulation of the mitochondrial proton gradient by cytosolic Ca2+ signals

Poburko, Damon ; Demaurex, Nicolas

In: Pflügers Archiv - European Journal of Physiology, 2012, vol. 464, no. 1, p. 19-26