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Consortium of Swiss Academic Libraries

Measuring Populist Attitudes on Three Dimensions

Schulz, Anne ; Müller, Philipp ; Schemer, Christian ; Wirz, Dominique Stefanie ; Wettstein, Martin ; Wirth, Werner

In: International Journal of Public Opinion Research, 2018, vol. 30, no. 2, p. 316-326

Université de Fribourg

Low prevalence of lactase persistence in bronze age europe indicates ongoing strong selection over the last 3,000 years

Burger, Joachim ; Link, Vivian ; Blöcher, Jens ; Schulz, Anna ; Sell, Christian ; Pochon, Zoé ; Diekmann, Yoan ; Žegarac, Aleksandra ; Hofmanová, Zuzana ; Winkelbach, Laura ; Reyna-Blanco, Carlos S. ; Bieker, Vanessa ; Orschiedt, Jörg ; Brinker, Ute ; Scheu, Amelie ; Leuenberger, Christoph ; Bertino, Thomas S. ; Bollongino, Ruth ; Lidke, Gundula ; Stefanović, Sofija ; Jantzen, Detlef ; Kaiser, Elke ; Terberger, Thomas ; Thomas, Mark G. ; Veeramah, Krishna R. ; Wegmann, Daniel

In: Current Biology, 2020, p. -

Lactase persistence (LP), the continued expression of lactase into adulthood, is the most strongly selected single gene trait over the last 10,000 years in multiple human populations. It has been posited that the primary allele causing LP among Eurasians, rs4988235-A [1], only rose to appreciable frequencies during the Bronze and Iron Ages [2, 3], long after humans started consuming milk from...

Université de Fribourg

EEF1A1 deacetylation enables transcriptional activation of remyelination

Duman, Mert ; Vaquié, Adrien ; Nocera, Gianluigi ; Heller, Manfred ; Stumpe, Michael ; Sankar, Devanarayanan Siva ; Dengjel, Jörn ; Meijer, Dies ; Yamaguchi, Teppei ; Matthias, Patrick ; Zeis, Thomas ; Schaeren-Wiemers, Nicole ; Hayoz, Antoinette ; Ruff, Sophie ; Jacob, Claire

In: Nature Communications, 2020, vol. 11, no. 1, p. 3420

Remyelination of the peripheral and central nervous systems (PNS and CNS, respectively) is a prerequisite for functional recovery after lesion. However, this process is not always optimal and becomes inefficient in the course of multiple sclerosis. Here we show that, when acetylated, eukaryotic elongation factor 1A1 (eEF1A1) negatively regulates PNS and CNS remyelination. Acetylated eEF1A1...

Université de Fribourg

Analysis method for detecting topological defect dark matter with a global magnetometer network

Masia-Roig, Hector ; A.Smiga, Joseph ; Budker, Dmitry ; Dumont, Vincent ; Gruji, Zoran ; Kim, Dongok ; Kimball, Derek F. Jackson ; Lebedev, Victor ; Monroy, Madeline ; Pustelny, Szymon ; Scholtes, Theo ; Segura, Perrin C. ; Semertzidi, Yannis K. ; Shin, Yun Chang ; Stalnaker, Jason E. ; Sulai, Ibrahim ; Weis, Antoine ; Wickenbrock, Arne

In: Physics of the Dark Universe, 2020, vol. 28, p. 100494

The Global Network of Optical Magnetometers for Exotic physics searches (GNOME) is a network of time-synchronized, geographically separated, optically pumped atomic magnetometers that is being used to search for correlated transient signals heralding exotic physics. GNOME is sensitive to exotic couplings of atomic spins to certain classes of dark matter candidates, such as axions. This work...

Università della Svizzera italiana

The C-terminal domain of TPX2 is made of alpha-helical tandem repeats

Sanchez-Pulido, Luis ; Perez, Laurent ; Kuhn, Steffen ; Vernos, Isabelle ; Andrade-Navarro, Miguel A.

In: BMC structural biology, 2016, vol. 16, p. 17

Background: TPX2 (Targeting Protein for Xklp2) is essential for spindle assembly, activation of the mitotic kinase Aurora A and for triggering microtubule nucleation. Homologs of TPX2 in Chordata and plants were previously identified. Currently, proteins of the TPX2 family have little structural information and only small parts are covered by defined protein domains. Methods: We have used ...