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Université de Fribourg

Disruption of gamma–delta relationship related to working memory deficits in first-episode psychosis

Missonnier, Pascal ; Prévot, Anne ; Herrmann, François R. ; Ventura, Joseph ; Padée, Anna ; Merlo, Marco C. G.

In: Journal of Neural Transmission, 2020, vol. 127, no. 1, p. 103–115

Working memory (WM) deficits constitute a core symptom of schizophrenia. Inadequacy of WM maintenance in schizophrenia has been reported to reflect abnormalities in the excitation/inhibition (E/I) balance between pyramidal neurons and parvalbumin basket cells, which may explain alterations of the dynamics of gamma and delta oscillations. To address this issue, we assessed event-related gamma...