In: International journal of molecular sciences, 2021, vol. 22, no. 9, p. 16
Despite the huge body of research on osteogenic differentiation and bone tissue engineering, the translation potential of in vitro results still does not match the effort employed. One reason might be that the protocols used for in vitro research have inherent pitfalls. The synthetic glucocorticoid dexamethasone is commonly used in protocols for trilineage differentiation of human bone marrow...
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In: Cellular and Molecular Life Sciences, 2015, vol. 72, no. 4, p. 659-671
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In: Breast Cancer Research and Treatment, ///-
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In: International Journal of Molecular Sciences, 2019, vol. 20, no. 21, p. 5391
Malignant mesothelioma (MM) is an aggressive asbestos-linked neoplasm, characterized by dysregulation of signaling pathways. Due to intrinsic or acquired chemoresistance, MM treatment options remain limited. Calretinin is a Ca2+-binding protein expressed during MM tumorigenesis that activates the FAK signaling pathway, promoting invasion and epithelial-to-mesenchymal transition. Constitutive...
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In: Molecular oncology, 2017, vol. 11, p. 781–791
It was already in the 18th century when the French surgeon LeDran first noted that breast cancer patients with spread of tumor cells to their axillary lymph nodes had a drastically worse prognosis than patients without spread (LeDran et al., ). Since then, metastatic spread of cancer cells to regional lymph nodes has been established as the most important prognostic factor in many types of...
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In: Virchows Archiv, 2014, vol. 464, no. 3, p. 359-365
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In: Pediatric Surgery International, 2014, vol. 30, no. 2, p. 213-222
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In: Breast Cancer Research, 2018, vol. 20, no. 1, p. 104
Obesity is a strong predictor of poor prognosis in breast cancer, especially in postmenopausal women. In particular, tumors in obese patients tend to seed more distant metastases, although the biology behind this observation remains poorly understood.Methods: To elucidate the effects of the obese microenvironment on metastatic spread, we ovariectomized C57BL/6 J female mice and fed them...
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In: Journal of Mammary Gland Biology and Neoplasia, 2010, vol. 15, no. 3, p. 319-328
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In: Breast Cancer Research and Treatment, 2012, vol. 132, no. 3, p. 925-935
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