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Consortium of Swiss Academic Libraries

Glass ionomer cement in otological microsurgery: experience over 16years

Righini-Grunder, F. ; Häusler, R. ; Chongvisal, S. ; Caversaccio, M.

In: European Archives of Oto-Rhino-Laryngology, 2015, vol. 272, no. 10, p. 2749-2754

Consortium of Swiss Academic Libraries

Labyrinthine fenestration for stapes fixation in chronic ear disease others than otosclerosis

Zaugg, Yannick ; Linder, Thomas

In: European Archives of Oto-Rhino-Laryngology, 2015, vol. 272, no. 9, p. 2161-2166

Université de Fribourg

Distal and proximal hypoxia response elements cooperate to regulate organ-specific erythropoietin gene expression

Orlando, Ilaria M. C. ; Lafleur, Véronique N. ; Storti, Federica ; Spielmann, Patrick ; Crowther, Lisa ; Santambrogio, Sara ; Schödel, Johannes ; Hoogewijs, David ; Mole, David R. ; Wenger, Roland H.

In: Haematologica, 2019, vol. 105, no. 12, p. 2774–2784

While it is well-established that distal hypoxia response elements (HREs) regulate hypoxia-inducible factor (HIF) target genes such as erythropoietin (Epo), an interplay between multiple distal and proximal (promoter) HREs has not been described so far. Hepatic Epo expression is regulated by a HRE located downstream of the EPO gene, but this 3' HRE is dispensable for renal EPO gene...

Université de Fribourg

Hypoxia pathway proteins are master regulators of erythropoiesis

Watts, Deepika ; Gaete, Diana ; Rodriguez, Diego ; Hoogewijs, David ; Rauner, Martina ; Sormendi, Sundary ; Wielockx, Ben

In: International Journal of Molecular Sciences, 2020, vol. 21, no. 21, p. 8131

Erythropoiesis is a complex process driving the production of red blood cells. During homeostasis, adult erythropoiesis takes place in the bone marrow and is tightly controlled by erythropoietin (EPO), a central hormone mainly produced in renal EPO- producing cells. The expression of EPO is strictly regulated by local changes in oxygen partial pressure (pO2) as under-deprived oxygen (hypoxia);...

Université de Fribourg

Comparative analysis of the shape and size of the middle ear cavity of turtles reveals no correlation with habitat ecology

Foth, Christian ; Evers, Serjoscha W. ; Joyce, Walter G. ; Volpato, Virginie S. ; Benson, Roger B. J.

In: Journal of Anatomy, 2019, no. 0, p. -

The middle ear of turtles differs from other reptiles in being separated into two distinct compartments. Several ideas have been proposed as to why the middle ear is compartmentalized in turtles, most suggesting a relationship with underwater hearing. Extant turtle species span fully marine to strictly terrestrial habitats, and ecomorphological hypotheses of turtle hearing predict that this...

Consortium of Swiss Academic Libraries

Surgical planning tool for robotically assisted hearing aid implantation

Gerber, Nicolas ; Bell, Brett ; Gavaghan, Kate ; Weisstanner, Christian ; Caversaccio, Marco ; Weber, Stefan

In: International Journal of Computer Assisted Radiology and Surgery, 2014, vol. 9, no. 1, p. 11-20