Affiner les résultats

Type de document

Collection spécifique

Langue

Université de Fribourg

Lipid droplet biogenesis from specialized ER subdomains

Choudhary, Vineet ; Schneiter, Roger

In: Microbial Cell, 2020, vol. 7, no. 8, p. 218–221

Lipid droplets (LDs) are cellular compartments dedicated to the storage of metabolic energy in the form of neutral lipids, commonly known as “fat”. The biogenesis of LDs takes place in the endoplasmic reticulum (ER), but its spatial and temporal organization is poorly understood. How exactly sites of LD formation are selected and the succession of proteins and lipids needed to mediate...

Université de Fribourg

Seipin and Nem1 establish discrete ER subdomains to initiate yeast lipid droplet biogenesis

Choudhary, Vineet ; El Atab, Ola ; Mizzon, Giulia ; Prinz, William A. ; Schneiter, Roger

In: Journal of Cell Biology, 2020, vol. 219, no. 7, p. -

Lipid droplets (LDs) are fat storage organelles that originate from the endoplasmic reticulum (ER). Relatively little is known about how sites of LD formation are selected and which proteins/lipids are necessary for the process. Here, we show that LDs induced by the yeast triacylglycerol (TAG)-synthases Lro1 and Dga1 are formed at discrete ER subdomains defined by seipin (Fld1), and a...

Consortium of Swiss Academic Libraries

Mechanism and Significance of Chlorophyll Breakdown

Christ, Bastien ; Hörtensteiner, Stefan

In: Journal of Plant Growth Regulation, 2014, vol. 33, no. 1, p. 4-20

Université de Fribourg

Adaptation to fluctuating environments in a selection experiment with Drosophila melanogaster

Kubrak, Olga I. ; Nylin, Sören ; Flatt, Thomas ; Nässel, Dick R. ; Leimar, Olof

In: Ecology and Evolution, 2017, vol. 7, no. 11, p. 3796–3807

A fundamental question in life‐history evolution is how organisms cope with fluctuating environments, including variation between stressful and benign conditions. For short‐ lived organisms, environments commonly vary between generations. Using a novel experimental design, we exposed wild‐derived Drosophila melanogaster to three different selection regimes: one where generations...