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Dietary potassium and the renal control of salt balance and blood pressure

Penton, David

In: Pflügers Archiv : European Journal of Physiology, ///-

ENaC activity in collecting ducts modulates NCC in cirrhotic mice

Mordasini, David ; Loffing-Cueni, Dominique ; Loffing, Johannes ; Beatrice, Rohrbach ; Maillard, Marc ; Hummler, Edith ; Burnier, Michel ; Escher, Geneviève ; Vogt, Bruno

In: Pflügers Archiv - European Journal of Physiology, 2015, vol. 467, no. 12, p. 2529-2539

Human intestine luminal ACE2 and amino acid transporter expression increased by ACE-inhibitors

Vuille-dit-Bille, Raphael ; Camargo, Simone ; Emmenegger, Luca ; Sasse, Tom ; Kummer, Eva ; Jando, Julia ; Hamie, Qeumars ; Meier, Chantal ; Hunziker, Schirin ; Forras-Kaufmann, Zsofia ; Kuyumcu, Sena ; Fox, Mark ; Schwizer, Werner ; Fried, Michael ; Lindenmeyer, Maja ; Götze, Oliver ; Verrey, François

In: Amino Acids, 2015, vol. 47, no. 4, p. 693-705

Albumin evokes Ca 2+ -induced cell oxidative stress and apoptosis through TRPM2 channel in renal collecting duct cells reduced by curcumin

Nazıroğlu, Mustafa ; Çiğ, Bilal ; Yazğan, Yener ; Schwaerzer, Gerburg K. ; Theilig, Franziska ; Pecze, László

In: Scientific Reports, 2019, vol. 9, no. 1, p. 1–16

In proteinuric nephropathies of chronic kidney disease, the epithelial cells of the nephron including the collecting duct are exposed to high concentrations of luminal albumin. Albumin is taken up from collecting duct cells by endocytosis causing excessive reactive oxygen species (ROS) production and a proinflammatory response. Curcumin used in the traditional medicine possesses...

Retromer and TBC1D5 maintain late endosomal RAB7 domains to enable amino acid–induced mTORC1 signaling

Kvainickas, Arunas ; Nägele, Heike ; Qi, Wenjing ; Dokládal, Ladislav ; Jimenez-Orgaz, Ana ; Stehl, Luca ; Gangurde, Dipak ; Zhao, Qian ; Hu, Zehan ; Dengjel, Jörn ; Virgilio, Claudio De ; Baumeister, Ralf ; Steinberg, Florian

In: The Journal of Cell Biology, 2019, vol. 218, no. 9, p. 3019–3038

Retromer is an evolutionarily conserved multiprotein complex that orchestrates the endocytic recycling of integral membrane proteins. Here, we demonstrate that retromer is also required to maintain lysosomal amino acid signaling through mTORC1 across species. Without retromer, amino acids no longer stimulate mTORC1 translocation to the lysosomal membrane, which leads to a loss of mTORC1...

The atypical receptor CCRL2 (C-C Chemokine Receptor-Like 2) does not act as a decoy receptor in endothelial cells

Mazzotti, Chiara ; Gagliostro, Vincenzo ; Bosisio, Daniela ; Del Prete, Annalisa ; Tiberio, Laura ; Thelen, Marcus ; Sozzani, Silvano

In: Frontiers in immunology, 2017, vol. 8, p. 1233

C-C chemokine receptor-like 2 (CCRL2) is a non-signaling seven-transmembrane domain (7-TMD) receptor related to the atypical chemokine receptor (ACKR) family. ACKRs bind chemokines but do not activate G protein-dependent signaling or cell functions. ACKRs were shown to regulate immune functions in vivo by their ability to scavenge chemokines from the local environment. This study was ...

P2Y2 receptor activation inhibits the expression of the sodium-chloride cotransporter NCC in distal convoluted tubule cells

Gailly, P. ; Szutkowska, M. ; Olinger, E. ; Debaix, H. ; Seghers, F. ; Janas, S. ; Vallon, V. ; Devuyst, O.

In: Pflügers Archiv - European Journal of Physiology, 2014, vol. 466, no. 11, p. 2035-2047

A primary culture system of mouse thick ascending limb cells with preserved function and uromodulin processing

Glaudemans, Bob ; Terryn, Sara ; Gölz, Nadine ; Brunati, Martina ; Cattaneo, Angela ; Bachi, Angela ; Al-Qusairi, Lama ; Ziegler, Urs ; Staub, Olivier ; Rampoldi, Luca ; Devuyst, Olivier

In: Pflügers Archiv - European Journal of Physiology, 2014, vol. 466, no. 2, p. 343-356

The SLC6 transporters: perspectives on structure, functions, regulation, and models for transporter dysfunction

Rudnick, Gary ; Krämer, Reinhard ; Blakely, Randy ; Murphy, Dennis ; Verrey, Francois

In: Pflügers Archiv - European Journal of Physiology, 2014, vol. 466, no. 1, p. 25-42

A rapid enzymatic method for the isolation of defined kidney tubule fragments from mouse

Wagner, Carsten ; Lükewille, Ulrike ; Valles, Patricia ; Breton, Sylvie ; Brown, Dennis ; Giebisch, Gerhard ; Geibel, John

In: Pflügers Archiv, 2003, vol. 446, no. 5, p. 623-632